Merrimack Pharmaceuticals, Inc.

Stephen Su

Alexey Alexandrovich Lugovskoy

Eric Krauland

Neeraj Kohli

Brian Harms

Melissa Geddie

William George Roach

Adnan Abu-Yousif

Provided herein are tandem Fcs and tandem Fc antibodies ('TFcAs'), e.g., tandem Fc bispecific antibodies ('TFcBAs'), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs bind to the cell surface receptors c-Met and EpCam and inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.

ANTI-C-MET tandem Fc bispecific antibodies

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Boston, MA, United States of America

Stephen Su