Cell Design Labs, Inc.

Arsenal Biosciences, Inc.

Stephen Santoro

Peter Emtage

Scott Coyle

Levi Rupp

Katherine Harris

Natalie Bezman

Anzhi Yao

Aaron Cooper

John Gagnon

Michelle Nguyen

Harbani Kaur Malik Chaudhry

Omar Khan

Adam Litterman

Nicole Allen

Stephanie Secrest

Jasper Williams

Provided herein are chimeric antigen receptors that binds specifically to B-cell maturation antigen (BCMA) and CD307e, nucleic acids that encode these chimeric antigen receptors, and methods of making and using these chimeric antigen receptors.

Methods of making bispecific anti-CD307E and anti-BCMA chimeric antigen receptors and uses of the same

Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Immune cells having co-expressed shRNAS and logic gate systems

Methods and compositions are provided for reversibly localizing proteins to the exterior part of the cell surface. Compositions provided herein can include nucleic acids that encode polypeptides of interest and the ligand binding domain (LBD) of a nuclear hormone receptor. Medical applications are provided, including controlling the toxicity of CAR T cells.

Chimeric polypeptides and methods of altering the membrane localization of the same

Growing community of inventors

Daly City, CA, United States of America

Stephen Santoro