Boehringer Ingelheim Pharma Gmbh & Co Kg

Vernalis (oxford) Limited

Boehringer Ingelheim International Gmbh

Stephen Peter East

Georg Dahmann

Matthias Hoffmann

Guenter Linz

Gerhard Schaenzle

Andreas Schnapp

Sandra Handschuh

Lifen Wu

Edward Walker

Dennis Fiegen

Alessandra Bartolozzi

Achim Sauer

Mark Whittaker

Markus Ostermeier

John Scott

Clive Mccarthy

Jasna Klicic

Daniel Bischoff

Michael Philip Mazanetz

Patricia Amouzegh

Stefan Ludwig Michael Wollin

Someina Khor

Frederic Jacques Marlin

Robert John Scott

Spencer Charles R Napier

Eugene Richard Hickey

David Smith Thomson

Stefan Ludwig Wollin

Serge Gaston Convers-Reignier

Doris Riether

Jayne Samantha Bamford

The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein wherein n is either 0 or 1,

Substituted naphthyridines and their use as medicaments

Compounds of formula (I) have antibacterial activity; wherein Q represents a radical of formula &#x2014;N(OH)CH(&#x2550;O) or formula &#x2014;C(&#x2550;O)NH(OH); Y represents &#x2014;C(&#x2550;O)&#x2014;, &#x2014;C(&#x2550;S)&#x2014;, &#x2014;S(&#x2550;O)&#x2014;, or &#x2014;SO&#x2014;; Rrepresents hydrogen, C&#x2013;Calkyl or C&#x2013;Calkyl substituted by one or more halogen atoms, or, except when Q is a radical of formula &#x2014;N(OH)CH(&#x2550;O), a hydroxy, C&#x2013;Calkoxy, C&#x2013;Calkenyloxy, halogen, amino, C&#x2013;Calkylamino, or di-(C&#x2013;Calkyl)amino group; Rrepresents a substituted or unsubstituted C&#x2013;Calkyl, C&#x2013;Calkyl-O&#x2014;C&#x2013;Calkyl, C&#x2013;Calkyl-S&#x2014;C&#x2013;Calkyl, cycloalkyl(C&#x2013;Calkyl)-, aryl(C&#x2013;Calkyl)-, heterocyclyl(C&#x2013;Calkyl)-, or RRN&#x2014;C&#x2013;Calkyl group wherein Rrepresents hydrogen or C&#x2013;Calkyl and Rrepresents C&#x2013;Calkyl, or RRN-represents a cyclic amino group; Rand Rtaken together with the nitrogen atoms to which they are respectively attached form a saturated heterocyclic ring of from 4 to 7 ring atoms, which may be fused to a second carbocyclic or heterocyclic ring, either of which rings may optionally be substituted; and A represents a primary, secondary or tertiary amino group or a group &#x2014;R, &#x2014;OR, wherein Ris a substituted or unsubstituted C&#x2013;Calkyl, C&#x2013;Calkenyl, C&#x2013;Calkynyl, cycloalkyl, aryl, heterocyclyl, C&#x2013;Calkyl-O&#x2014;C&#x2013;Calkyl, C&#x2013;Calkyl-S&#x2014;C&#x2013;Calkyl, cycloalkyl(C&#x2013;Calkyl)-, heterocyclic(C&#x2013;Calkyl, aryl(C&#x2013;Calkyl)-or RRN&#x2014;C&#x2013;Calkyl group wherein Rrepresents hydrogen or C&#x2013;Calkyl and Rrepresents C&#x2013;Calkyl, or RRN-represents a cyclic amino group 

Antibacterial agents

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Abingdon, United Kingdom

Stephen Peter East