Gilead Sciences, Inc.

Other

Massachusetts Institute of Technology

Stephen Paul Lathrop

Andrew S Thompson

Brenda J Chan

Gregory Notte

Mark Andres

Ernest A Carra

Valeriya N Smolenskaya

Olga Viktorovna Lapina

Lars V Heumann

Brandon Heath Brown

Anna Chiu

Troy Evan Reynolds

Nolan Griggs

Brenda J Burke Chan

Lok Him Yu

Tao Wang

Mohammad Movassaghi

Christopher S Regens

Tiago Vieira

Jeffrey E Merit

Pavel Robertovich Badalov

Todd A Wenderski

Andrea Ambrosi

David Allen Siler

Zehua Zheng

Wen-Tau Timothy Chang

Matthew W Pompeo

Florence J Bachrach

Beau P Pritchett

Adam B Weinstein

Valeriya Smolenskaya

The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.

Processes for preparing toll-like receptor modulator compounds

Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.

Solid forms of an ASK1 inhibitor

A highly convergent biomimetic synthesis of a complex polycyclic scaffold has been successfully implemented. From these efforts, compounds having a structure of Formula (I): or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R-Rand m, n, r, s, t, and u are as defined herein, is provided. Methods of making such compounds are also disclosed as are methods for the treatment of cancer, various infectious diseases, and abnormal cardiovascular function.

Convergent and enantioselective total synthesis of Communesin analogs

Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide(Compound I) were prepared and characterized in the solid state:  Also provided are processes of manufacture and methods of using the crystalline forms.

A computer-driven printing system automatically adjusts inter-character spacing to account for the different visual effects that font scaling has on different ordered character pairs. The adjustment A(S, X.sub.j, X.sub.k) for a given size s and character pair (X.sub.j, X.sub.k) is computed from the formula:

Algorithmic character-space adjustment computed from

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San Mateo, CA, United States of America

Stephen Paul Lathrop