Pfizer Corporation

Stephen Paul Gibson

Christopher J Dutton

Ivan Tommasini

Richard Edward Armer

David Morris Gethin

Kelvin S Holdom

Alexander C Goudie

Nigel D Walshe

Bernard Joseph Banks

Brian S Bronk

Alan John Pettman

Graham Lunn

Robert James Crook

Shih-Jen E Lee

John D Bu'Lock

Kimberley Verrier

Thomas C Crawford

Lee Richard Roberts

Michael John Witty

Constantine Sklavounos

Douglas James Critcher

Christelle Lauret

Julian Duncan Smith

John D Bu'lock

Charles William Murtiashaw, Deceased

Neil Demers

The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents.

Antiparasitic agents

Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances. 

3-azabicyclo[3.1.0]hexane derivatives useful in therapy

There is provided a compound of formula I,wherein R, R, Rand Y have meanings given in the description, which are useful in the prophylaxis and in the treatment of pruritus.

Compounds useful in therapy

4-arylpiperidine derivatives for the treatment of pruritus

Novel compounds having general formula (I), and pharmaceutically and veterinarily acceptable salts thereof wherein R , R , R , W, Y , Y , X, n and y are as defined above and processes for their preparation and intermediate compounds prepared therein. The novel compounds are useful for having utility in the treatment of pruritic dermatoses including allergic dermatitis and atopy in animals and humans.

4-phenylpiperidines for the treatment of pruritic dermatoses

4-Arylpiperidine derivatives for the treatment of pruritus

Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances.

3-Azabicyclo&lsqb;3.1.0&rsqb;hexane derivatives useful in therapy

Antiparasitic avermectin derivatives of formula (I), where the broken line represents an optional bond, R.sup.1 and R.sup.4 are independently H, OH, halo, oximino, or an organic radical, R.sup.2, R.sup.6 and R.sup.7 are organic radicals and R.sup.3 is alpha-oleandrosyl or 4'-(alpha-oleandrosyl)-alpha-oleandrosyl optionally substituted at the 4'- or 4'-position, and R.sup.12 and R.sup.13 are independently H, CN, CONH.sub.2, C.sub.1 -C.sub.8 alkyl or aryl optionally substituted with at least one halo, OH, C.sub.1 -C.sub.8 alkylthio group.

Antiparastic auermectin derivatives

The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R.sup.1 when taken individually is H or OH; R and R.sup.1 when taken together represent a double bond;

Antiparasitic agents and process for their preparation

Compounds of the formula: ##STR1## wherein X represents a single or a double bond; R.sup.1 is H or OH; provided that when X is a single bond, R.sup.1 is H or OH, and when X is a double bond, R.sup.1 is absent;

Process for preparing antiparasitic agents

Process and antiparasitic intermediates for doramectin

Growing community of inventors

Sandwich, United Kingdom

Stephen Paul Gibson