Sumitomo Dainippon Pharma Oncology, Inc.

Stephen Patrick Anthony

David J Bearss

Steven L Warner

Adam Siddiqui-Jain

Clifford J Whatcott

Jason Marc Foulks

Paul Flynn

Yuka Arikawa

Yuji Fujiwara

Methods for treating a disease in a subject in need thereof by administering an ACVR1 inhibitor having the following formula (I) are disclosed: including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R, R, and Rare as defined herein. Subjects that may benefit from treatment may have mutations in their ACVR1 gene. Various diseases may be treated using the described methods, including cancers (e.g., diffuse intrinsic pontine glioma (DIPG)) and genetic disorders (e.g., fibrodysplasia ossificans progressiva (FOP)).

Methods for treating diseases associated with abnormal ACVR1 expression and ACVR1 inhibitors for use in the same

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Heber City, UT, United States of America

Stephen Patrick Anthony