University of California

Cold Spring Harbor Laboratory

Stephen P Bell

Jasper D Rine

Bruce W Stillman

Ira Herskowitz

Ryuji Kobayashi

Kimberly Gavin

Margit Foss

Joachim Li

Patricia Laurenson

Masumi Hidaka

Francis J McNally

Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.

Origin of replication complex genes

Origin of replication complex genes and methods of using the same

Growing community of inventors

Cold Spring Harbor, NY, United States of America

Stephen P Bell