University of Tennessee Research Foundation

The Uab Research Foundation

US Army Walter Reed Army Medical Center, Chief, Office of Research, Marketing & Policy Dev Walter Reed Army Institute of Research

Juntendo University School of Medicine, Division of Nephrology, Department of Internal Medicine

Stephen Olson

Yusuke Suzuki

Jan Novak

Jiri Mestecky

Robert J Wyatt

Yasuhiko Tomino

Milan Tomana

Bruce A Julian

Hitoshi Suzuki

Zina Moldoveanu

Matthew B Renfrow

Run Fan

Zhixin Zhang

Provided are methods of diagnosing IgA nephropathy in a subject. Optionally, the methods comprise isolating an IgG from the subject and determining whether the IgG binds to a galactose-deficient IgA1. Optionally, the methods comprise providing a biological sample from the subject and detecting in the sample a mutation in a IGH gene, wherein the mutation is in a nucleotide sequence encoding a complementarity determining region 3 (CDR3) of a IGH variable region. Optionally, the methods comprise determining a level of IgG specific for a galactose-deficient IgA1 in the subject. Also provided are methods of treating or reducing the risk of developing IgA nephropathy in a subject.

Diagnosing and treating IGA nephropathy

Growing community of inventors

Rockville, MD, United States of America

Stephen Olson