Micromass UK Limited

Stephen O'Brien

Ian David Trivett

David Gordon

Steven Derek Pringle

Daniel James Kenny

Emrys Jones

Anthony Hesse

Zoltan Takats

Stevan Bajic

Richard Barrington Moulds

Daniel Szalay

Lajos Godorhazy

Daniel Simon

Tamas Karancsi

Kate Whyatt

Alvin Chua

Matt Henderson

Graeme Dutton

Joseph A Jarrell

Edward Scott

Tamás Karancsi

Dániel Szalay

Lajos Gödörházy

Mike Morris

Dániel Simon

Peter Kerr

Zoltan Takáts

Zoltán TAKÁTS

An aperture plate assembly for an analytical instrument comprises a first sub-assembly comprising an aperture plate and a second sub-assembly comprising a guide. The first sub-assembly is configured to be attached to the second sub-assembly such that the aperture plate is positioned in a first position relative to the second sub-assembly. The first sub-assembly and the second sub-assembly are configured such that when the first sub-assembly is engaged by the guide, the aperture plate can be moved into the first position and the first sub-assembly can be attached to the second sub-assembly.

Aperture plate assembly

An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.

Collision surface for improved ionisation

An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.

There is provided an apparatus comprising a first ion source () arranged and adapted to emit a spray of charged droplets (), and a control system arranged and adapted to control one or more spatial properties of said spray of charged droplets () in use by automatically varying or adjusting one or more parameters of said first ion source.

Mass spectrometry imaging with automatic parameter varying in ion source to control charged droplet spraying

A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas conehaving an inlet aperture, wherein the gas conehas a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tubehaving an outlet and having a second longitudinal axis and a second capillary tubewhich surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tubeso that the liquid exits the outlet of the first capillary tubeat a flow rate &#x3e;200 &#x3bc;L/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tubeat a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tubeis arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tubeand the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heaterarranged and adapted to heat the desolvation gas to a temperature &#x2265;100&#xb0; C. and a fourth device arranged and adapted to supply a cone gas to the gas coneat a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

Miniature ion source of fixed geometry

An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body having a sampling orifice. The sampling limiting body comprises a nickel disk wherein the disk and sampling orifice are made or formed by an electroforming process.

Ion inlet assembly

An attachment device for releasably attaching a fluid line to a fluid inlet or outlet is disclosed. The device comprises an attachment member for releasably engaging a fluid inlet or outlet, and an elastic member coupled to the attachment member. The attachment device is attachable to a fluid line such that the attachment member is moveable relative to the fluid line and such that movement of the attachment member relative to the fluid line causes elastic deformation of the elastic member.

Probe assembly connector

An apparatus for connecting an ionization probe assembly to a mass and/or ion mobility spectrometer is disclosed. The apparatus comprises: an attachment member for releasably attaching a probe assembly to the apparatus; a cap for enclosing the attachment member; wherein the apparatus is operable to deliver a voltage to a probe assembly only when the cap is arranged to enclose the attachment member; and wherein the cap is configurable to enclose the attachment member when a probe assembly is attached to the apparatus.

Probe adaptor assembly

A mass spectrometer is disclosed comprising a first component, an annular vacuum chamber seal and a second component. The first component has a groove. The annular vacuum chamber seal comprises a main body portion and one or more blade or rib portions which protrude from the main body portion. The main body portion is located in the groove and the one or more blade or rib portions protrude above or beyond a surface of the first component. The second component is slid, in use, along the surface of the first component thereby deforming the one or more blade or rib portions so that the one or more blade or rib portions form a radial, diametric or piston seal between the first and second components.

Chamber seal for mass spectrometer

A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate &#x3e;200 &#x3bc;L/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater arranged and adapted to heat the desolvation gas to a temperature &#x2265;100&#xb0; C. and a fourth device arranged and adapted to supply a cone gas to the gas cone at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

An apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer is disclosed. The apparatus comprises: an attachment member for releasably attaching a probe assembly to the apparatus; a cap for enclosing the attachment member; wherein the apparatus is operable to deliver a voltage to a probe assembly only when the cap is arranged to enclose the attachment member; and wherein the cap is configurable to enclose the attachment member when a probe assembly is attached to the apparatus.

A gasket seal for a mass spectrometer is disclosed. The gasket seal comprises a membrane having an outer profile and an inner profile and one or more protrusions. One or more ports are provided in the body of the membrane. In use a gas or fluid is supplied through at least one of the one or more ports via at least one of the one or more protrusions.

Growing community of inventors

Manchester, United Kingdom

Stephen O'Brien