C. R. Bard, Inc.

Davol Inc.

Stephen N Eldridge

Roger E Darois

Michael John Lee

Jon I Montcrieff

Scott Narkevicius

Frederick H Strickler, Jr

Valerie L Vadurro

Christopher W Gelinas

Sarah B Borysenko

Kevin J Ranucci

Dennis Cherok

Anthony Trupiano

Donald Anthony Coelho, Jr

Milo A Titone

Francis B Maddalo

Robert D Torgerson

Donald Anthony Coelho

Paul Vonryll Gryska

Brendan J McCrea

John Uhoch

Philip A Tessier

Steven Palmer Ford

Ronald L Greene

Alan W Robbins

Ira M Rutkow

Mark V Iampietro

Paul vonRyll Gryska

Barbara Kelley

Matthew R Fenton

Raymond C Duhamel

Patrick J Devlin

Kelly M Shriner

Implant

The present invention is an implantable adhesive mesh prosthesis for reinforcing and/or repairing a defect in tissue that is easy to roll into a small diameter cylinder or other low-profile shape for passing through a trocar, incision, or other surgical instrument. More specifically, the adhesive may be applied to the mesh material in a pattern that leaves a significant portion of the surface area of the mesh material free of adhesive. In one embodiment, the adhesive is applied only near the outer perimeter of the mesh product. In another embodiment, the adhesive is applied in spots over all or a portion the surface of the mesh product. In yet another embodiment, the adhesive is applied in parallel lines on the surface of the mesh product and the mesh may be rolled up around an axis parallel to the lines of adhesive.

Self adhering implantable mesh prosthesis with reduced insertion profile

An implantable prosthesis is provided for repairing or augmenting anatomical weaknesses or defects, and is particularly suitable for the repair of soft tissue and muscle wall openings. The prosthesis may include a repair fabric that is constructed and arranged to allow tissue ingrowth and is susceptible to erosion into and the formation of adhesions with tissue and organs. One or more regions of the prosthesis may be configured to inhibit erosion into and/or the formation of adhesions with tissue and organs. The prosthesis may include an erosion resistant edge to buffer an edge of the fabric from the adjacent tissue or organs. The erosion resistant edge may be provided along an opening that is adapted to receive a tube-like structure, such as the esophagus.

Prosthetic repair fabric with erosion resistant edge

An implantable prosthesis for an anatomical defect, such as a tissue or muscle defect, that promotes tissue or muscle growth into the prosthesis and subsequently strengthens the area of the defect. At least one pocket and preferably two concentric pockets may be provided to aid with manipulating the prosthesis. Where two pockets are used, a barrier or partition exists between the pockets and the outer pocket allows manipulation of the outer periphery. The incidence of postoperative adhesions between a portion of the prosthesis and tissue, muscle or organs may be minimized with the use of a barrier layer. Reinforcing members may be attached to portions of the prosthesis to aid in positioning and deployment in the area of desired coverage without rendering the prosthesis unduly difficult to implant or uncomfortable for the patient. Typically, two concentric members are employed. Further, the prosthesis is constructed to allow it to be provisionally held in place at desired locations by openings in the pockets that allow access for a stapler or sewing device.

Implantable prosthesis

An implantable prosthesis is provided for repairing or augmenting anatomical weaknesses or defects, and is particularly suitable for the repair of soft tissue and muscle wall openings. The prosthesis includes a repair fabric with a generally triangular-shaped body and two tails extending outward from the base of the triangular body. The tails may be rounded to provide the repair fabric with a generally heart-shaped configuration. An opening is provided along the base of the body and between the two tails for receiving a tube-like structure, such as the esophagus. The prosthesis may include a layer of fabric that is constructed and arranged to allow tissue ingrowth and is susceptible to erosion into and the formation of adhesions with tissue and organs. One or more regions of the prosthesis may be configured to inhibit erosion into and/or the formation of adhesions with tissue and organs. The prosthesis may include an edge barrier that is attached to the tails and overlies a portion of the opening. A portion of the edge barrier may be folded into the opening to isolate the tube-like structure from an edge of the opening.

Prosthetic repair fabric

An implantable prosthesis is provided for repairing or augmenting anatomical weaknesses or defects, and is particularly suitable for the repair of soft tissue and muscle wall openings. The prosthesis is configured to promote enhanced tissue ingrowth thereto, while limiting the incidence of post-operative adhesions between the fabric and tissue or organs. The prosthesis may include a layer of fabric that is constructed and arranged to allow tissue ingrowth and is susceptible to the formation of adhesions for tissue and organs. One or more barriers may be provided on selected portions of the fabric to inhibit the formation of adhesions with tissues and organs. The prosthesis may have an opening that is adapted to receive the esophagus or other tube-like structure, or other projection, that passes through an opening in or projects from a tissue, muscle or organ wall requiring repair and/or augmentation. The prosthesis may be configured for use in hiatal hernia repair and/or treatment of GERD. A method is also provided for the treatment of GERD.

An implantable prosthesis is provided for repairing or augmenting anatomical weaknesses or defects, and is particularly suitable for the repair of soft tissue and muscle wall openings. The prosthesis may include a layer of fabric that is constructed and arranged to allow tissue ingrowth and is susceptible to erosion into and the formation of adhesions with tissue and organs. The prosthesis is configured to inhibit edge erosion of the prosthesis into surrounding tissue and organs. The prosthesis may include an erosion resistant edge to buffer an edge of the fabric from the adjacent tissue or organs. The erosion resistant edge may be provided along an opening that is adapted to receive a tube-like structure, such as the esophagus.

A hemostatic device formed of collagen particles and methods for producing and using the hemostatic device to control bleeding are provided. The collagen particles of the hemostatic device have a hemostatic activity that is equivalent to the hemostatic activity of the collagen particles from which the hemostatic device is formed. More preferably, the hemostatic devices are formed of Avitene&reg; flour and the collagen particles of the hemostatic devices of the invention have a hemostatic activity equivalent to the hemostatic activity of Avitene&reg; flour. The hemostatic devices optionally include hemostatic agents and/or therapeutic agents, to further promote hemostasis and wound healing.

Collagen hemostatic foam

A collagen fiber and methods for producing and using the collagen fiber of the inventions to prepare hemostatic fabrics to control bleeding are provided. The collagen particles (e.g., fibrils) of the fiber, preferably, have a hemostatic activity that is equivalent to the hemostatic activity of the collagen particles from which the fiber is formed. The collagen fibers of the invention and hemostatic fabrics formed thereof optionally include hemostatic agents and/or other therapeutic agents, to further promote hemostasis and wound healing.

Collagen hemostatic fibers

A prosthetic repair fabric including a sheet of tissue infiltratable fabric and a second sheet, also preferably including tissue infiltratable fabric, which is united with the first sheet. The second sheet is fused to an adhesion resistant barrier, forming a laminate composite prosthesis without degrading the mechanical properties or tissue ingrowith capability of the first sheet.

A prosthetic repair fabric and method for repairing an inguinal hernia in the inguinal canal. The prosthesis including a layer of mesh fabric that is susceptible to the formations of adhesions with sensitive tissue and organs, and a barrier layer that inhibits the formation of adhesions with sensitive tissue and organs. The mesh fabric including a medial section and a lateral section that are configured to be positioned adjacent the medial corner and the lateral end of the inguinal canal, respectively, when the prosthesis is placed in the inguinal canal to repair the defect. The barrier layer is positioned on the mesh fabric to inhibit the formation of adhesions between the spermatic cord and the mesh fabric. At least a portion of the lateral section of the mesh fabric is free of the barrier layer on both of its sides to promote enhanced tissue ingrowth therein. The barrier layer may include at least one flap that is to be folded through the mesh fabric to isolate the spermatic cord from internal edges of the fabric when the spermatic cord is routed through the prothesis.

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Exeter, RI, United States of America

Stephen N Eldridge