University of Georgia Research Foundation, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Thermo Fisher Scientific Gmbh

Stephen Mark Tompkins

Ralph A Tripp

Mathias D Viard

Jon Michael Karpilow

Robert P Blumenthal

Robert Jeff Hogan

Yossef Raviv

Mark Steven Oberste

Disclosed are compositions and methods for increasing influenza virus production.

Methods and compositions related to increased influenza virus production

Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picornavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.

Cell lines for virus production and methods of use

The invention provides compositions of inactivated influenza virus that can be used as vaccines and immunological compositions useful for inhibiting, preventing and treating influenza.

Inactivated influenza virus compositions

Growing community of inventors

Watkinsville, GA, United States of America

Stephen Mark Tompkins