Cardiovascular Imaging Systems, Inc.

Integrated Vascular Systems, Inc.

C. R. Bard, Inc.

Core Medical, Inc.

Other

Cardinal Health Switzerland 515 Gmbh

Stephen M Salmon

Yue-Teh Jang

Richard S Ginn

David Allan White

Ronald J Jabba

William N Aldrich

Anthony J Pantages

Michael T Carley

W Martin Belef

Paul G Yock

Javier Sagastegui

Rizza A Garcia

Steven Nelson Roe

Mark L Pomeranz

John R McKenzie

Peter Thornton

William Martin Belef

Francisco Javier Sagastegui

Thomas J Palermo

Veijo T Suorsa

L Venkata Raman

Robert M Scribner

Pat A Gingell

Rizza Casasos

A closure system and methods of use are provided for use in sealing an opening in a body tissue, such as a vascular puncture site. A method of closing the opening in the body tissue can be performed with the closure system having a closure clip. The method can include positioning the closure clip in a first closure clip position adjacent to the opening in the body tissue such that a plurality of spikes of the closure clip are inserted into the tissue at a location outward from a central axis of the opening. Subsequently, the closure clip can be positioned in a second closure clip position such that the plurality of spikes are pulled inward toward the central axis of the opening so as to pull the tissue between the opening and each of the spikes together and close the opening.

Closure system and methods of use

An apparatus for sealing a passage through tissue includes a bioabsorbable body disposed on a distal end of a handle device. The plug member includes a helical thread on its outer surface and the plug member and handle device include cooperating lumens communicating with a distal port. A sealing member is disposed within the plug member lumen. An obturator is inserted through the lumens until its distal tip extends beyond the plug member, the distal tip including a bleed back port. The plug member is threaded into a passage towards a blood vessel until the bleed back indicator identifies the location of the vessel with respect to the plug member. The plug member is released from the handle device, the handle device and obturator are withdrawn, and the sealing member seals the lumen. The plug member is left within the passage to seal the passage until the tissue heals.

Apparatus and methods for sealing vascular punctures

An apparatus for sealing a passage through tissue communicating with a body lumen is provided. The apparatus includes an elongate member having a proximal end a distal end and a lumen extending from the distal end toward the proximal end defining a longitudinal axis. A plug member is disposed on the distal end and extends distally from the elongate member in a pre-deployed and deployed configuration. The plug member includes a distal port therein in communication with the lumen and has a cross-sectional diameter at a plug proximal end and a plug distal end greater than a cross-sectional diameter of the distal end of the elongate member in the pre-deployed configuration. The apparatus also includes a member extendable distally from the distal port, the member including a proximal end and a distal end.

An apparatus for delivering a clip to close an opening through tissue includes a sheath and a carrier assembly including a clip therein that is slidable on the sheath. An actuator assembly is connectable to the sheath, and telescoping actuator members extend from the handle that are connectable to the carrier assembly for advancing the carrier assembly along the sheath. An obturator on the actuator assembly includes splines that may be deployed beyond a distal end of the sheath, and expanded to a transverse expanded configuration for positioning the sheath before deploying the clip. The actuator members include cooperating detents that selectively release the actuator members as the carrier assembly reaches predetermined positions along the sheath for deploying the clip from the carrier assembly, and that collapse the splines to allow removal of the apparatus after deploying the clip.

Apparatus and methods for delivering a closure device

A catheter system has a balloon angioplasty device disposed about a common lumen near its distal end. The balloon catheter is pre-fitted with a stent which is deployed when the balloon is inflated. The common lumen is in communication with multiple lumens within a proximal region of the catheter body to allow for positioning of the catheter over a movable guide wire and convenient delivery of imaging or interventional devices to a desired region of a body passageway being treated. The procedure for stent deployment optionally includes steps of imaging a lumen by ultrasound before and after stent deployment to identify the site at which a stent is needed, to confirm that the stent is being and has been deployed at a longitudinal position which does not overlap a branched segment of the body passageway, and to ensure that the stent has been radially opened to an optimum diameter.

Catheter system having imaging, balloon angioplasty, and stent deployment capabilities, and method of use for guided stent deployment

An apparatus for sealing a passage through tissue includes an elongate shaft and a cylindrical plug disposed on a distal end of the shaft, the plug including a helical thread on its outer surface. Intestinal submucosa may be secured to the plug, e.g., in a cavity in its distal end, that may be delivered into the passage. Alternatively, the plug may be formed from a bioabsorbable material and may be released from the shaft within the passage. The plug is threaded into the passage, thereby engaging the tissue to seal the passage. The shaft is rotated until it engages a blood vessel within the tissue while monitoring blood flow through the vessel. The shaft is rotated to thread the plug into the passage until blood flow ceases through the vessel, whereupon rotation of the shaft is reversed to back the plug until blood flow through the vessel resumes.

Devices for sealing openings through tissue and apparatus and methods for delivering them

Catheter system having imaging, balloon angioplasty, and stent

A catheter exchange member is provided for reducing exchange time when replacing one catheter (or similar device) with another in the vascular anatomy of a patient. The catheter exchange member includes a tubular body having a proximal and a distal end and a central lumen. A tapered fixture having a distal port and a proximal opening which is larger than the distal port is attached to the tubular body at the distal port. An elongate shaft is attached to and extends proximally from either the tapered fixture or the tubular body. The exchange member is preferably used within a conventional guiding catheter where the tubular body is advanced through a distal end of the guiding catheter and into the coronary artery while the tapered fixture remains in the guiding catheter. This configuration allows various therapeutic and diagnostic devices to be stored within the guiding catheter just proximal to the tapered fixture. One of the devices can be placed within the coronary artery by simply advancing it through the tapered fixture which channels the device into the tubular body and into the coronary artery. The device may be replaced with another by simply removing it and advancing the second device into the tapered fixture and into the coronary artery

Rapid exchange delivery catheter

Apparatus and method are described for introducing an imaging catheter to the coronary vasculature. A guiding catheter is introduced so that the distal end of the guiding catheter engages a coronary os. The distal end of the guiding catheter is shaped so that a mark on the distal end is oriented in a predetermined orientation relative to the coronary vasculature. An imaging catheter is then introduced through the guiding catheter and an image of the mark is produced with the imaging catheter while in the guiding catheter. In this manner, the relative orientation of the produced image and the coronary vasculature is known.

Rotational correlation of intravascular ultrasound image with guide

In one aspect, the invention provides a vascular catheter sheath for use with a therapeutic catheter having a radially expandable member. The catheter sheath includes a catheter body having a proximal end, a distal end, and at least one lumen adapted to receive the therapeutic catheter. The catheter body further includes a compliant portion near the distal end, with the compliant portion being adaptable to conform to the shape of the expandable member when the expandable member is radially expanded in the lumen.

Methods for using catheters having compliant lumens

Compliant catheter lumen and methods

Growing community of inventors

Sunnyvale, CA, United States of America

Stephen M Salmon