Ciba-geigy Corporation

Ciba Vision Corporation

Stephen M Martin

Fu-Pao Tsao

Thomas Edward Rowe

Harold Shlevin

A container, composition and method for preserving treatment solutions, in which the composition includes weak and strong preservatives. The dispensing container includes media within a dispensing tip which media removes or alters the strong preservative, while allowing the weak preservative to inhibit microbial growth in the tip media. The dispensing container is especially useful in delivering to the ocular environment ophthalmic solutions which are essentially free of strong preservative which may cause patient discomfort. A dispensing container including a pH-preserved pilocarpine solution is disclosed in one embodiment.

Methods and composition for preserving media in the tip of a solution

A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

Method of preserving ophthalmic solution and compositions therefor

Method of preserving ophthalmic solutions and compositions therefor

Container for preserving media in the tip of a solution dispenser

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Roswell, GA, United States of America

Stephen M Martin