The Uab Research Foundation

Stephen M Manzella

Elias Meezan

This present invention provides a method and compounds for priming the incorporation of cellular glucose into an oligosaccharide in a cell comprising administering to the cell a priming amount of a membrane-permeating nontoxic glycoside having a suitable hydrophobic organic group joined by a linkage to a suitable hydrophilic saccharide, wherein the hydrophilic saccharide has a nonreducing terminal sugar residue selected from the group consisting of glucose or xylose, thereby priming the incorporation of cellular glucose onto the glycoside to form an oligosaccharide. Also disclosed are methods wherein the administration of the glycoside is sufficient to treat diabetes mellitus and glycogen storage disease.

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Birmingham, AL, United States of America

Stephen M Manzella