Ich Productions Limited

Ucl Business Plc

Imperial College of Science, Technology and Medicine

Ucl Biomedica Plc

Ryboquin Company Limited

University College London

Stephen Lewis Hart

Michele Writer

Helen Claire Hailes

Alethea Bernice Tabor

Aristides Tagalakis

John Bosco Wong

Christopher Hurley

Martin Elbs

Mohd Firouz Mohd Mustapa

Michael Pilkington-Miksa

Richard P Harbottle

Mohn Firouz Mohd Mustapa

Stephanie Grosse

Richard Paul Harbottle

A non-viral delivery complex comprising a cationic core which is a nanoparticle comprising a peptide having a polycationic nucleic acid binding component, a cleavable spacer element and a cell surface receptor binding component; a nucleic acid and optionally a cationic lipid; and an anionic liposomal coating surrounding the cationic core, said coating comprising lipids from a subject's cells. Also related formulations, uses and methods.

Anionic nanocomplexes for nucleic acid delivery

A lipid comprising a tri-chain cation having a cationic head group and three or more Chydrocarbyl groups for use in non-viral gene delivery systems, for example in the formation of lipopolyplex transfection vectors. Exceptionally good nucleic acid transfection is observed when nucleic acid and targeting peptides are formulated with the lipid of the invention (or lipid formulated with a co-lipid) into a LPD complex.

Lipids and complexes for the delivery of biologically-active material to cells

The invention provides a peptide derivative of formula A-B-C wherein The invention also provides a lipid derivative of general formula (I):(PEG)-Linker-Spacer-Cationic headgroup-carbon skeleton-(hydrophobic chain)wherein: The peptide and lipid derivatives find use in non-viral gene delivery systems.

Materials and complexes for the delivery of biologically-active materials to cells

The invention provides a peptide having at least 3 amino acids comprising an amino acid sequence selected from in which Xis a basic amino acid residue, Xis Q or P, Xis A or T, Xis an acidic amino acid residue and Xis P or Q. The invention further provides non-viral cell-targeting vector complexes and methods associated therewith.

Transfection complexes

A peptide consisting of or comprising an amino acid sequence selected from

Peptide ligands

The invention provides a lipid of general formula (I) or (II): wherein X, Xand Rto Rare as defined herein. Such lipids are used to form complexes with a biologically-active material such as a nucleic acid, peptide or small molecule for delivering the biologically-active material to cells. The complexes may incorporate an integrin-binding peptide and, when the biologically-active material is DNA, thereby constitute a LID complex.

Materials for the delivery of biologically-active material to cells

The invention provides a peptide having at least 3 amino acids comprising an amino acid sequence selected from a) XSM [SEQ.ID.NO.:1] b) LXHK [SEQ.ID.NO.:2] c) PSGXARA [SEQ.ID.NO.:9] d) SXRSMNF [SEQ.ID. NO.:16] e) LXHKSMP [SEQ.ID.NO.:18] in which X is a basic amino acid residue, Xis Q or P, Xis A or T, Xis an acidic amino acid residue and Xis P or Q, the invention further provides non-viral cell-targeting vector complexes and methods associated therewith.

A complex that comprises (i) a nucleic acid, (ii) an integrin-binding component, for example, an integrin-binding peptide, (iii) a polycationic nucleic acid-binding component, for example, oligolysine, and (iv) a lipid component, for example, a cationic liposome, has transfection activity.

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Stephen Lewis Hart