Exelixis, Inc.

Nortel Networks Corporation

Other

Rockstar Consortium US LP

Stephen Lau

Dana T Aftab

Nathan Guz

Noel Hamill

Tracy Walker

Jana Galbraith

Simon Yau

Tal Isaac Lavian

Khalid Ali Shah

Lyndon Y Ong

The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Crystalline Solid forms of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Crystalline solid forms of N-{4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl} -n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

Crystalline solid forms of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

An apparatus and method for dynamic assignment of classes of traffic to a priority queue. Bandwidth consumption by one or more types of packet traffic received in the packet forwarding device is monitored to determine whether the bandwidth consumption exceeds a threshold. If the bandwidth consumption exceeds the threshold, assignment of at least one type of packet traffic of the one or more types of packet traffic is changed from a queue having a first priority to a queue having a second priority.

Dynamic assignment of traffic classes to a priority queue in a packet forwarding device

A method and apparatus for automatically configuring a network switch having external network data ports, a processor, and memory. Network data is monitored on the external network data port. Information about the network data traffic is compared to one or more threshold conditions. The network switch is automatically configured if the network data meets one of the threshold conditions. The monitor and configuration functions can be performed by software running on the processor which has been downloaded from an external network maintenance station through a maintenance data port. Information about the network data traffic can be uploaded to the external network maintenance station through a maintenance data port.

Method and apparatus for automatically configuring a network switch

Growing community of inventors

South San Francisco, CA, United States of America

Stephen Lau