Takeda Pharmaceutical Company Limited

Takeda San Diego, Inc.

Takeda California, Inc.

Array Biopharma Inc.

Takeda Pharmaceutical Company Limied

Global Blood Therapeutics, Inc.

Stephen L Gwaltney

Jun Feng

Jeffrey Alan Stafford

Zhiyuan Zhang

Michael Brennan Wallace

Stephen W Kaldor

Paul Isbester

Grant Jackson Palmer

Mingnam Tang

Bruce Joseph Elder

Luckner Gerard Ulysse

Jonathon Stuart Salsbury

Zacharia S Cheruvallath

Mark Sabat

Prasuna Guntupalli

Sheldon Cao

Joanne Miura

Brian Walter Metcalf

Zhe Li

Qing Xu

Laurence Edward Burgess

Scott D Cowen

Jason R Harris

Haxia Wang

Xiao-Yi Xiao

Betty Lam

Calvin Wesley Yee

Andrew John Jennings

Beverly Lynn Wolgast

Robert J Skene

David J Hosfield

Zhlyuan Zhang

Jeongboeb Seo

Ellen Ruth Laird

Edcon Chang

Yan Liu

Sripathy Venkatraman

Haixia Wang

Bingidimi Itute Mobele

Richard S Fornicola

Paul R Brodfuehrer

Yasuhisa Kohara

Angie Vassar

Maxwell M Reeve

David J Hossfield

Paul R Brodfuahrer

Philip B Kisanga

Hidehisa Iwata

Jonathan S Salsbury

Stephen S Gonzales

Xiaodong Wang

ZhiYuan Zhang

Paul K Isbester

Sheldon X Cao

Beverly Throop

Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Glucokinase activators

Pyrazole and fused pyrazole glucokinase activators

Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Compounds are provided which have the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture which contain such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to activate glucokinase.

Substituted isoindoles as glucokinase activators

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR; Qand Qare each independently selected from the group consisting of CO, SO, SO, and C&#x2550;NR; and each L, X, R, R, and Rare as defined herein.

Dipeptidyl peptidase inhibitors

Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase. 

The present invention relates to apoptosis signal-regulating kinase 1 ('ASK1') inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Apoptosis signal-regulating kinase 1 inhibitors

The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:&#x2014;wherein the variables are as defined herein. 

Renin inhibitors

Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein. 

Imidazopyridine compounds

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO, or C&#x2550;NR, and L, X, Z, Rand Rare as defined herein.

Growing community of inventors

San Diego, CA, United States of America

Stephen L Gwaltney