Arch Development Corporation

Stephen L Gluck

F Gary Toback

Margaret M Walsh-Reitz

Autocrine growth factors and isoforms of those factors have been identified, isolated, purified and manipulated. Nucleic acid segments coding for the factors, and antibodies directed to the factors are also aspects of the present invention. The effect of these growth factors on cells is to enhance their growth by increasing mitogenesis. In particular, the growth factors stimulate kidney epithelial cell growth. The growth factors differ from others previously reported in their molecular weights and other properties, for example, resistance to denaturation by dithiothreitol. Methods of preparation and use of the factors are also described. The growth factors are released from kidney epithelial cells by short exposures to a low-sodium environment. The factors have potential for treatment of kidney disease.

Regeneration of kidney tissue and use of autocrine growth factors

Methods and compositions for the preparation and use of autocrine growth

A method of producing autocrine growth factors from kidney epithelial cells by lowering the extracellular sodium concentration. The invention also concerns new growth factors, a method of producing the new growth factors, and the medium used to produce these new growth factors.

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St. Louis, MO, United States of America

Stephen L Gluck