Sionex Corporation

Sri International

Dh Technologies Development Pte. Ltd.

Renishaw Diagnostics Limited

Stephen L Coy

Erkinjon G Nazarov

Raanan A Miller

C James Morris

Gary Alan Eiceman

John A Wright

Evgeny Krylov

Edward T Bullister

Joseph R Stetter

Alexander Hallock

Lawrence H Dubois

David B Wheeler

Douglas B Cameron

Quan Shi

Stephen D Kendig

Gareth S Dobson

Michael Coggiola

Michael J Vestel

Caterina Netti

Richard Copeland

Detecting and identifying ions using surface enhanced Raman spectroscopy (SERS) and an ion separation pre-filter, such as an ion spectrometer, are provided. The combination of an ion separator as a pre-filter for SERS provides a highly sensitive detector with very low false alarm rates. Target ions from an ionized sample are identified and separated by the ion separator. The target ions are steered and deposited onto a SERS substrate for Raman spectroscopic analysis with an optical probe. The Raman spectrum is compared with reference spectra and the composition of the sample is identified. The ion current from the target ions can also be measured, preferably concurrently with the Raman spectrum measurement. Types of ion separators include a differential ion mobility spectrometer, an ion mobility spectrometer, or a mass spectrometer.

Surface enhanced Raman spectroscopy detection with ion separation pre-filter

An ultra compact ion mobility based analyzer in a multilayered chip assembly employing various features such as a ion flow generator to propel ions through an ion mobility based filter and, thereby, reduce analyzer size, cost, and power requirements.

Ultra compact ion mobility based analyzer apparatus, method, and system

The invention provides, in various embodiments, systems and methods relating to enhancing the filtering and detection capability of ion mobility based systems by various techniques to counteract a charge buildup in the ion mobility based system.

Method and apparatus for enhanced ion based sample filtering and detection

The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample detection using enhanced condition control and data interpretation.

Systems and methods for ion species analysis with enhanced condition control and data interpretation

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Wayland, MA, United States of America

Stephen L Coy