Sirtex Medical Limited

Paragon Medical, Inc.

Stephen Keith Jones

Bruce Nathaniel Gray

Raffaele Cammarano

Katrina Francis Rutherford

A magnetic material having a magnetic heating efficiency of at least 4.5&times;10 J.m/A.g in a cyclic magnetic field where the product of the amplitude and frequency of the applied field is less than or equal to 5&times;10 A/m.s, and the frequency of the applied filed is at least 20 kHz. The ideal magnetic material is characterized by a perfectly rectangular hysteresis loop, i.e. loop squareness of 1, with coercivity of 25 kA/m or less and high saturation magnetization. Preferably the magnetic material has a predominately cubic magnetic crystalline anisotropy. Preferably the magnetic material is a substituted magnetite (Fe O ) or &ggr;-ferric oxide (&ggr;Fe O ) crystalline lattice in which some of the iron atoms in that crystalline lattice have been substituted for one or more alternate metals atoms. Desirably, the metal atom is a member of the group: cobalt, zinc, nickel, manganese, magnesium, copper, chromium, gallium, cadmium.

Heating of magnetic material by hysteresis effects

A method for site specific treatment of diseased tissue in a patient, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5&times;10 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5&times;10 A/s; (ii) delivering the magnetic material to diseased tissue in a patient; and (iii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5&times;10 A/s to generate hysteresis heat in the diseased tissue.

Targeted hysteresis hyperthermia as a method for treating diseased tissue

The present invention provides an improved method for treatment of diseased tissue, which comprises the steps of:

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Leederville, Australia

Stephen Keith Jones