Gilead Sciences, Inc.

Boehringer Ingelheim International Gmbh

Boehringer Ingelheim (canada) Ltd.

Stephen Kawai

Youla S Tsantrizos

Bruno Simoneau

Lee Fader

Murray D Bailey

Rebekah J Carson

Sebastien Morin

Marc-Andre Poupart

Christian Brochu

Serge R Landry

Francois Bilodeau

Mathieu Parisien

Pierre Louis Beaulieu

Christiane Yoakim

Teddy Halmos

Catherine Chabot

Carl Thibeault

Simon Surprenant

Rene Coulombe

Steven LaPlante

Steven R Laplante

Jean Rancourt

Jeffrey O'Meara

Bounkham Thavonekham

Marc-André Poupart

William W Ogilvie

Paul John Edwards

Eric Jolicoeur

Robert D&eacute;ziel

Timothy A Stammers

Araz Jakalian

François Bilodeau

Punit K Bhardwaj

Steven Laplantea

Punit-Kumar Bhardwaj

Paul J Edwards

René Coulombe

Sébastien Morin

Compounds of formula I: wherein a, R, R, R, R, Rand Rare defined herein, are useful as inhibitors of HIV replication.

Inhibitors of human immunodeficiency virus replication

Compounds of formula I: wherein R, Rand Rare defined herein, are useful as inhibitors of HIV replication.

Compounds of formula (I): wherein c, X, Y, R, Rand Rare defined herein, are useful as inhibitors of HIV replication. 

Compounds of formula I: wherein c, R, R, R, R, R, Rand Rare defined herein, are useful as inhibitors of HIV replication. 

The present invention relates to compounds of formula (I) wherein c, X, Y, R, R, Rand Rare as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.

An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R, R, L, M, M, M, M, Y, Y, Z and Sp are as defined in claimor a salt thereof, as an inhibitor of HCV NS5B polymerase.

Viral polymerase inhibitors

A compound, represented by formula (I): wherein A, B, R, R, R, R, R, R, R, and Rare as defined herein, or an enantiomer, diastereoisomer or tautomer thereof, including a salt, ester or derivative thereof, as an inhibitor of HCV NS5B polymerase.

An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein wherein A, B, R, R, L, M, M, M, M, Y, Y, Z and Sp are as defined in claim, or a salt thereof, as an inhibitor of HCV NS5B polymerase.

Azetidinone derivatives for the treatment of HCMV infections

Growing community of inventors

Montreal, Canada

Stephen Kawai