Corning Incorporated

Coming Incorporated

Stephen Joseph Caracci

Yue Zhou

David Andrew Pastel

Qi Wu

David Henry

Sean Matthew Garner

Robert Adam Modavis

Mark Alan Lewis

Adam J Fusco

Jessica Jo Kelley

Eric John Mozdy

Cheng-Chung Li

Thomas Mark Leslie

Norman Henry Fontaine

Dana Craig Bookbinder

Stephan Lvovich Logunov

William James Miller

Ann MeeJin Ferrie

Ye Fang

John David Downie

Mark Francis Krol

Daniel Raymond Sempolinski

Po Ki Yuen

Thomas Moore

Michael Brian Webb

Michael Edward DeRosa

Anthony Glenn Frutos

Alain R E Carre

Christophe Nicolas

Robert G Lindquist

Gordon M Shedd

Lingyan Wang

Michael Joseph Dailey, Jr

Mircea Despa

Edward L Jones

Mark D Salik

James V Suggs

Yan Jin

Xuequn Hu

Rui-Qing Ma

Volker H O Eckelt

Deepti J Mudaliar

Alfredo D Botet

An aqueous cell culture medium composition includes an aqueous cell culture solution configured to support the culture of mammalian cells. The composition further includes a synthetic polymer conjugated to a polypeptide dissolved in the aqueous cell culture solution. The synthetic polymer conjugated to a polypeptide is configured to attach to the surface of a cell culture article under cell culture conditions. Incubation of the aqueous cell culture medium composition on a cell culture surface under cell culture conditions results is attachment to the surface of the synthetic polymer conjugated to the polypeptide.

Synthetic attachment medium for cell culture

Magnetic microcarrier beads have a particle size of 1 to 1000 micrometers and include a composite core and a polymer coating that surrounds and encapsulates the core. The composite core includes magnetic particles embedded within an indigestible polymer matrix. The coating is a digestible or indigestible polymer that facilitates cell adhesion to the surface of the beads during cell culture. Magnetic force can be used to agitate the microcarrier beads during cell culture as well as to separate the beads from cultured cells or processed bio-media.

Magnetic microcarriers

A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

Label-free high throughput biomolecular screening system and method

A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.

Multi-channel swept wavelength optical interrogation system and method for using same

An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

Optical interrogation system and method for using same

Optical interrogation systems and methods are described herein that are capable of measuring the angles (or changes in the angles) at which light reflects, transmits, scatters, or is emitted from an array of sensors or specimens that are distributed over a large area 2-dimensional array.

Arrayed sensor measurement system and method

The present invention provides methods for forming convex and concave elements on the ends of supporting members. A convex element may be formed by forming a droplet on the end of the supporting member, then curing the droplet. The size of the droplet may be controlled using evaporation of a solvent from the droplet. In another aspect of the invention, an optical element may be formed by forming a droplet on the end of the supporting member, contacting the droplet with a mold, and curing the droplet, thereby forming an element with a curvature opposite that of the mold. When the supporting member is an optical fiber, the elements formed by the methods of the present invention are useful as lenses and mirrors in micro-optic devices.

Method for fabricating curved elements

An optical interrogation system and method are described herein that are capable of generating light beams that have desired optical properties which are directed towards a specimen array. In one embodiment, the optical interrogation system includes a light source, a diffractive element and a collimating optic (e.g., simple lens(es), f-&#x3b8; lens(es), segmented mirror, fiber array). The light source emits a light beam to the diffractive optic which receives the light beam and outputs an array of light beams to the collimating optic. The collimating optic receives and conditions the light beams emitted from the diffractive optic and then outputs the conditioned light beams which have desired optical properties towards a specimen array. Several other embodiments of the optical interrogation system are also described herein.

A grating-coupled waveguide (GCW) and a method are described herein that can be used to detect the presence of a biological substance (e.g., cell, drug, chemical compound) in a sensing region of the GCW. The GCW includes a substrate, a diffraction grating and a waveguide film that has a higher index of refraction than the substrate which has an index of refraction&#x2266;1.5. The relatively low-index substrate effectively increases the sensitivity of the GCW by causing the waveguide mode to shift towards a biological substance located in a sensing region above the waveguide film, thereby increasing the field strength of the mode's evanescent tail in this region. In one embodiment, an array of the GCWs are incorporated within the wells of a microplate.

Substrate index modification for increasing the sensitivity of grating-coupled waveguides

Articles and methods for positioning lensed fiber elements and optical devices are disclosed. The articles and methods include a lens gripping element and a fiber gripping element disposed on a planar substrate. The articles and methods are useful for manufacturing optical fiber and lens arrays and waveguide devices.

Fiber and lens grippers, optical devices and methods of manufacture

Articles and methods for manufacturing pigtailed planar optical devices are disclosed. The articles and methods include providing a tool including a substrate having a stepped region. The tool is capable of forming elements such as grippers or waveguides on a device substrate having different heights.

Passive alignment of optical fibers with optical elements

The present invention is an optical signal device having transceiver elements and interference filters held in a transparent mounting structure. The interference filters are deposited onto prisms, and may be individually held in the mounting structure, or assembled together as a subassembly. The present invention is especially useful as a transceiver for local area network and fiber to the home applications.

Optical signal device

Growing community of inventors

Elmira, NY, United States of America

Stephen Joseph Caracci