General Electric Company

Stephen Johnson Lomnes

Siavash Yazdanfar

Vernon Jensen

Floribertus P M Heukensfeldt Jansen

Kajoli Banerjee Krishnan

Tiberiu Mircea Siclovan

Pavel Alexeyevich Fomitchov

Michael Christopher Montalto

Cristina Abucay Tan Hehir

Xinghua Wang

Floribertus Heukensfeldt Jansen

Kenneth Michael Fish

Tunchiao Hubert Lam

Deborah Stutz Lee

Stephen Andrew Latham

A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.

Methods and systems of optical imaging for target detection in a scattering medium

Multimodal optical imaging is disclosed. Possible devices include a filter assembly that is capable of rotary action during real time image acquisition. Systems are disclosed that include such filter assemblies, which are detachable or integrated in the systems. Various techniques for capturing image targets using multiple light sources such as white light and fluorescent light are also disclosed.

Multimodal optical imaging

The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.

Myelin detection using benzofuran derivatives

A technique is provided for imaging based on localization of fluorescence in a medium. The technique includes illuminating the medium with an excitation light to excite fluorescence, scanning the medium at a plurality of locations via an ultrasonic beam, modulating a portion of the emitted light from the fluorescence via the ultrasonic beam at each of the plurality of locations, differentially detecting the modulated light at a boundary of the medium, and reconstructing an image from the detected signal.

System and method for imaging based on ultrasonic tagging of light

A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.

Method and system of optical imaging for target detection in a scattering medium

A system provides a multi-axis translation and orientation capability for optical imaging. The system includes an optical imaging apparatus providing a signal representing a digitized image, and a mechanical frame. The frame includes a first set of articulations capable of independently translating the optical imaging apparatus in multiple linear directions. The system also includes a second set of articulations formed as joints providing at least three independent degrees of rotation of the optical imaging apparatus. The system also provides an opening configured to permit the frame to be postured about a patient such that an isocenter corresponds to a region of interest of the patient, and includes an illumination source attached to the frame and configured to direct illumination towards the isocenter. The system also comprises a camera system co-located with the illumination source and having a focal plane at the isocenter.

Growing community of inventors

Albany, NY, United States of America

Stephen Johnson Lomnes