Wyeth

Stephen John Freese

Kathrin Ute Jansen

Annaliesa Sybil Anderson

Bruce Arthur Green

A Krishna Prasad

Viliam Pavliak

Ingrid Lea Scully

Jasdeep Singh Nanra

Tracy Dee Scott

Ingrid Lea Dodge

Annaliesa Anderson

The present invention relates to immunogenic conjugates comprisingserotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carbonyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

[object Object]

The present invention relates to immunogenic conjugates comprisingserotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

Growing community of inventors

Cornwall-on-Hudson, NY, United States of America

Stephen John Freese