Smith + Nephew

University of Strathclyde

Stephen John Curran

Jonathan Nicholas Ridgway

Graham Smith

Stephen Andrew Latham

Mark F Smith

Marc Walter Tanner

Mark Howard

Michael Pratt

Nick Reback

Pei-Sheng Chen

Elizabeth Finnie

Elisabeth Hutson

Richard A Black

James Blackhurst

Mark Smith

The present disclosure relates to a tissue collection apparatus including a housing defining an inlet and an outlet and a tissue scaffold suitable for disposal within the housing, the tissue scaffold configured to be loaded with the tissue under the application of an aspiration force applied through the tissue collection apparatus.

Tissue harvesting

The invention relates to a method and apparatus to continuously monitor and control acoustic energy and vacuum pressure to maintain a net unidirectional flow of multi-phase heterogeneous fluids through a porous filter or membrane. The heterogeneous fluid may come form a variety of sources including biological sources such as, blood, bone marrow aspirate (BMA), adipose tissue (lipoaspirate), urine, saliva, etc.

Controller for an acoustic standing wave generation device in order to prevent clogging of a filter

The invention relates to a method and apparatus to continuously monitor and control acoustic energy and vacuum pressure to maintain a net unidirectional flow of multi-phase heterogeneous fluids through a porous filter or membrane. The heterogenous fluid may come form a variety of sources including biological sources such as, blood, bone marrow aspirate (BMA), adipose tissue (lipoaspirate), urine, saliva, etc.

The present application is directed to the separation of a solid fraction from a fluid sample particularly a therapeutic cellular fraction from a biological sample such as a bone marrow sample by a porous filter which separates a filtration unit into an upper pre-filtration chamber into which a fluid sample requiring cell separation is introduced and a lower post-filtration chamber into which a fluid capable of transmitting an acoustic standing wave is introduced. An acoustic element is coupled to a substrate which is located within and at the bottom of the lower chamber and which resonates in response to the acoustic generating element and generates a standing wave through the two fluid phases and the filter to agitate the sample. Simultaneously, a cyclic process of vacuum draw, causes movement of the sample downwards through the filter. Vacuum pressure, fluid flow rate and frequency of vibration are controlled from a remote unit housing appropriate pumps and valves.

Apparatus and method for filter cleaning by ultrasound, backwashing and filter movement during the filtration of biological samples

A biological or chemical reactor () has an inner vessel () disposed within an outer vessel () and an annular space () defined therebetween in which fluid is to be contained. The fluid comprises reactants of a biological or chemical reaction. A reaction support () is disposed in an opening in a wall of one of the vessels and is designed to support a structure such as a scaffold that receives fluid under pressure from the annular space. The reactor generates hydrodynamic pressure and shear stress in the fluid within the annular space, upon relative rotational movement between the vessels so as to drive the fluid through intersticies in the scaffold.

Reactor comprising an annular reaction space

The present application is directed to the separation of&#x2014;a solid fraction from a fluid sample particularly a therapeutic cellular fraction from a biological sample such as a bone marrow sample by a porous filter () which separates a filtration unit () into an upper pre-filtration chamber () into which a fluid sample () requiring cell separation is introduced and a lower post-filtration chamber () into which a fluid () capable of transmitting an acoustic standing wave is introduced. An acoustic element () is coupled to a substrate () which is located within and at the bottom of the lower chamber () and which resonates in response to the acoustic generating element () and generates a standing wave through the two fluid phases and the filter to agitate the sample (). Simultaneously, a cyclic process of vacuum draw (). causes movement of the sample () downwards through the filter (). Vacuum pressure, fluid flow rate and frequency of vibration are controlled from a remote unit housing appropriate pumps and valves.

Growing community of inventors

York, United Kingdom

Stephen John Curran