Cytomx Therapeutics, Inc.

Genzyme Corporation

Other

Bioverativ USA Inc.

Stephen James Moore

Olga Vasiljeva

Daniel Robert Hostetter

James William West

Margaret Thy Luu Nguyen

Jason Gary Sagert

Jonathan Alexander Terrett

Sherry Lynn La Porte

Graham Parry

Jeanne Grace Flandez

Li Mei

Margaret T L Nguyen

Michael Storek

Nina C Leksa

Sandip Panicker

Pavel A Nikitin

Tony Byun

Daniel R Hostetter

The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix metalloprotease (MMP) and at least a second cleavable moiety (CM2) that is a substrate for at least one serine protease (SP), to activatable antibodies and other larger molecules that include these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease, and to methods of making and using these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease in a variety of therapeutic, diagnostic and prophylactic indications.

Matrix metalloprotease-cleavable and serine protease-cleavable substrates and methods of use thereof

The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.

Protease-resistant systems for polypeptide display and methods of making and using thereof

Provided herein are humanized anti-factor Bb antibodies, methods of producing the antibodies and methods of using the antibodies.

Humanized anti-complement factor Bb antibodies and uses thereof

The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (uPA), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator in a variety of therapeutic, diagnostic and prophylactic indications.

Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof

The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.

Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof

Humanized anti-complement factor Bb antibodies

The present disclosure provides methods of inducing a complement activity on a surface of a cell comprising contacting the cell with an effective amount of an anti-Factor B antibody, wherein the anti-Factor B antibody inhibits dissociation of a C3bBb complex into a Factor Bb and a C3b.

Methods of inducing complement activity

The invention relates generally to antibodies that bind programmed death ligand 1 (PDL1), activatable antibodies that specifically bind to PDL1 and methods of making and using these anti-PDL1 antibodies and anti-PDL1 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of use thereof

Growing community of inventors

Livermore, CA, United States of America

Stephen James Moore