Microchips, Inc.

Focal, Inc.

Genzyme Corporation

C. R. Bard, Inc.

Massachusetts Institute of Technology

Cardiopulmonary Corporation

Endosphere Surgical, Inc.

Andre Bieniarz

Stephen Jack Herman

John T Santini, Jr

Jeffrey Alan Hubbell

Laurence A Roth

Scott Albert Uhland

Norman F Sheppard, Jr

Benjamin F Polito

John M Maloney

Amarpreet S Sawhney

George E Selecman

Vae E Sun

Stephen C Rowe

Frederick F Ahari

Michael F Lang

Michael John Cima

Patrick K Campbell

Dennis Ausiello

Chandrashekhar Prabhakar Pathak

Arthur J Coury

Peter K Jarrett

Kevin M Berrigan

Robert Samuel Langer

Barry Mitchell Yomtov

Dean M Pichon

Barry Y Yomtov

Farhad Khosravi

Edward L Sinofsky

David A Melanson

J Jeffrey Kablik

Bradley C Poff

Michael G Dumont

James H Prescott

Thomas Bromander

David J Enscore

Douglas M Johnston

James W Biondi

Mark Staples

Jacob Y Wong

Vivek A Sikri

Arthur C Mckinley

John C Spiridigliozzi

Melvin B Prenovitz

John M Kirwan

Glenn Kazo

Jesse R Plouffe

Carl R Turnquist

Douglas W Dickinson

Jeffrey A Hubbell

Norman F Sheppard

Rebecca S Shawgo

John T Santini Jr

A cannula assembly includes a tubular element forming a lumen, a deployable element of a subassembly, and an electronic component mounted to the deployable element. The tubular element has a proximal end and a distal end adapted to be inserted into a body cavity. The deployable element is coupled through the subassembly to the tubular element, and is adapted to transition between a closed position and an open position. The electronic component has at least one imaging device and at least one illumination source. The subassembly, including the deployable element and the electronic component, are releasable from the tubular element.

Cannula with integrated camera and illumination

Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.

Method and system for drug delivery to the eye

Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

Implantable device for controlled, extended delivery of parathyroid hormone

Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

Containment device with multi-layer reservoir cap structure

Medical devices, utilizing multiple reservoirs to protect and selectively expose sensors or other reservoir contents, are provided having (i) a reservoir contents destruction mechanism to interrupt the release or exposure of reservoir contents, for example, to deactivate an unneeded sensor and prevent it from negatively impacting other sensors, (ii) a protective covering material layer over the sensor underneath the reservoir cap, which protects the sensor membrane and sensor during reservoir cap disintegration and then is removed, (iii) a device design for containing sensors in shallow, wide reservoir structures to enhance sensor exposure by minimizing molecular diffusion distances, (iv) an implantable sensor unit and a separate drug delivery unit, or (v) combinations thereof.

Medical device for sensing glucose

Medical device and methods are provided for controlled drug delivery in a cardiac patient. The device includes an implantable drug delivery module comprising reservoirs containing a drug and a control means for selectively releasing an effective amount of drug from each reservoir; one or more electrodes or sensors for cardiac monitoring, stimulation, or both; and a microcontroller for controlling operational interaction of the drug delivery module and the cardiac electrode. The electrodes may comprise ECG monitoring, cardioversion, or cardiac pacing electrodes. A medical device also is provided for controlled delivery of drug to a patient having congestive heart failure, which includes an implantable drug delivery module comprising a natriuretic peptide and a release mechanism for selectively releasing a pharmaceutically effective amount of the natriuretic peptide into the patient; and a microcontroller for controlling the release mechanism, for example, in response to one or more monitored patient parameters.

Medical device for controlled drug delivery and cardiac monitoring and/or stimulation

Devices and methods for the controlled release or exposure of reservoir contents, and methods of manufacture thereof, are provided. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. The controlled release system may be incorporated into an implantable drug delivery or biosensing device.

Method for making device for controlled reservoir opening by electrothermal ablation

Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.

Medical device for neural stimulation and controlled drug delivery

A drug delivery device for implantation into a patient is provided that includes at least one device element that includes a substrate having a plurality of discrete reservoirs disposed therein, the reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, wherein the drug delivery device is adapted to conform to a curved bone tissue surface. In one embodiment, the substrate is flexible and conforms to a bone tissue surface. In another embodiment, the device has two or more device elements attached to or integral with a flexible supporting layer.

Implantable, tissue conforming drug delivery device

Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.

Multi-reservoir device for transdermal drug delivery and sensing

Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

Controlled release device and method using electrothermal ablation

Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.

Hermetically sealed microchip reservoir devices

Method and device for the controlled delivery of parathyroid hormone

Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.

Microchip reservoir devices using wireless transmission of power and data

Growing community of inventors

Andover, MA, United States of America

Stephen Jack Herman