Wisconsin Alumni Research Foundation

The University of Chicago

Stephen J Wright

James Blake Rawlings

Richard J Quigg

Gabriele Pannocchia

Ridgway Scott

Stuart A Kurtz

Terry Clark

Chris (Hristem) Dyanov

A partial enumeration model predictive controller and method of predictive control for a multiple input, multiple output (MIMO) system, including providing a solution table with problem solutions to a model predictive control problem for the MIMO system over a partial parameter region; scanning the solution table for an optimal solution for current parameters; using the optimal solution to control the MIMO system when the optimal solution is in the solution table; and using an alternative solution to control the MIMO system when the optimal solution is not in the solution table.

Partial enumeration model predictive controller

A method for determining a matrix of expression levels corresponding to a set of biological targets (e.g., genes or gene fragments) and a set of biological samples, including obtaining a matrix of signal values corresponding to the set of biological targets; computing a vector of expression levels for a sample in the set of biological samples using the matrix of signal values; storing the vector of computed expression levels in a storage matrix; repeating the computing and storing steps for each sample in the set of biological samples; and outputting the storage matrix as the matrix of expression levels. The method, based on a linear programming formulation of the problem, works for both 'promiscuous' probe array data, in which there may be multiple targets indicated by a single probe, and the 'polygamous' case, in which there are multiple probes for a single target. The preferred method can also process data obtained from multiple SAGE analyses using multiple markers. A second embodiment of the method determines optimal expression levels when the available probe data is noisy or uncertain.

Method for determining biological expression levels by linear programming

Growing community of inventors

Madison, WI, United States of America

Stephen J Wright