Johnson & Johnson Medical Gmbh

Johnson & Johnson Products, Inc.

Johnson & Johnson Patient Care, Inc.

Ethicon, Gmbh

Stephen J Wolf

Lowell G Saferstein

David M Wiseman

Scott C Otto

Robert K Mart

Cary B Linsky

James P Dellas

Julius A Lindquist

Lola Kamp

An improved adhesion-preventative physical barrier, wound dressing and drug delivery system comprising an oxidized cellulose film made up of multiple layers of a cellulose fabric or like material and a cellulose film. A method for forming an improved oxidized cellulose film and for using the same to prevent the formation of postsurgical adhesions and/or to dress a wound and/or to deliver one or more drugs.

Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions

A hemostatic paste composition comprising a hemostatic effective amount of thrombin in a polyethylene glycol base which is preferably prepared by admixing an aqueous solution of thrombin and polyethylene glycol and freeze-drying the mixture to remove substantially all of the water to yield a viscous water soluble paste of fine particles of thrombin uniformly dispersed throughout the polyethylene glycol base, and methods of its use to provide hemostasis to a hemorrhaging site of a mammal.

Hemostatic thrombin paste composition

Oxidized cellulose material is neutralized, by contacting an acidic oxidized cellulose material with a water and alcohol solution of a basic salt of a weak organic acid, e.g. sodium acetate, to elevate the pH of the cellulosic material to between 5 and 8. The resulting neutralized product is storage stable and has therapeutic applications, including hemostasis and adhesion prevention. Furthermore, the neutralized product may be impregnated with acid-sensitive hemostatic agents, such as thrombin, to enhance its hemostatic properties, or with acid-sensitive adhesion-preventive agents, such as t-PA, to enhace its adhesion-prevention properties.

Process for preparing a neutralized oxidized cellulose product and its

A locking holder is disclosed which describes a pair of flanges separated by a transverse arm. The flanges are adapted to receive a syringe placed on either side of the arm. One of the flanges contains a channel. This channel is adapted to enclose the gripping ears on the syringe. Generally, the ears lock into the channel by rotating roughly a quarter-turn when placed in the channel.

Locking holder for a pair of syringes and method of use

A fluid delivery system where two reactive fluids are delivered simultaneously and separately from a pair of syringes to a delivery site. In one embodiment, a length of tubing exits one syringe and passes through a cannula exiting from the other syringe, to deliver both fluids, separately, but in a controlled volume and space to the delivery site. Alternately, the fluids can mix within the cannula, but its configuration prevents clogging at the delivery site.

Two component syringe delivery system

A hemostatic collagen paste composition comprising a mixture, by weight of the total composition, of 2 to 30% of crosslinked collagen powder of 10 to 100 mesh particle size and 30 to 98% of water or an aqueous saline solution and hemostatic paste compositions that also comprise a hemostatic enhancing amount of thrombin, as well as methods of making and using such hemostatic collagen paste compositions.

Hemostatic collagen paste composition

A spray syringe is disclosed which includes in combination a hypodermic syringe and a tubular member having a spray orifice at a distal tip. The tubular member is flexible permitting orientation of the spray orifice independent of the orientation of the syringe. The tubular member is sized such that the needle of the syringe is received within the bore in a fluid tight seal.

Spray nozzle for syringe

A process is disclosed for delivery thrombin in dry powdered form from an aerosol container by first lyophilizing an aqueous solution of thrombin and a thrombin-compatible synthetic polymer e.g. polyvinyl pyrrolidone, placing the lyophilized cake in a pressure bottle by crimping on a valve stem and top, filling liquified chlorofluoroalkane-containing aerosol propellant into the bottle, and actuating the valve to dispense in dry-finely divided powdered form a mixture of thrombin and polyvinyl pyrrolidone, which powdered thrombin is for use in controlling bleeding during surgery.

Thrombin aerosol

Hemostatic adhesive bandages are disclosed wherein a very thin coating of a high molecular weight polyethylene oxide is applied to the surface of the perforated plastic film wound release cover of an adhesive bandage, in a manner compatible with commonly used high speed production techniques and equipment, which stop the bleeding faster when applied to minor cuts.

Growing community of inventors

Manville, NJ, United States of America

Stephen J Wolf