Amgen Inc.

Stephen J Shuttleworth

Rajiv Sharma

Jinqian Liu

Julio Cesar Medina

Jonathan B Houze

Frank Kayser

Liusheng Zhu

Jian Luo

Zhihua Ma

Jiwen Liu

Christopher Neil Farthing

Yingcai Wang

Sarah Lively

Jian Zhang

Michael J Schmitt

Alexander David Frenkel

Daniel C H Lin

Ying Sun

Wei Qiu

Michelle Akerman

Jeffrey D Reagan

Martin J Harrison

David Craig McGowan

Xiaoqi Chen

Juan Carlos Jaen

Xiaotian Zhu

Jeffrey Thomas Mihalic

David John Kopecky

Leping Li

Xi Chen

Richard V Connors

Erin F DiMauro

Mike Elias Lizarzaburu

John Laird Buchanan

XianYun Jiao

Kang Dai

Yong-Jae Kim

William H Buckner

Simon A Burkitt

Teresa L Marshall

Ying Fu

Paul Faulder

Jinqain Liu

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ-L-P-L-M-X-L-Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

The present invention relates to furanopyrimidine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.

Furanopyrimidines

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ&#x2014;L&#x2014;P&#x2014;L&#x2014;M&#x2014;X&#x2014;L&#x2014;Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disorders and eating disorders. 

Substituted benzofused heterocycles

Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided herein.

Pyrrolo[2,3-d]pyrimidines that modulate ACK1 activity

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Bourne End, United Kingdom

Stephen J Shuttleworth