Rainin Instrument Co., Inc.

Nellcor Puritan Bennett Incorporated

Nellcor Incorporated

Aradigm Corporation

Altex Scientific, Inc.

Stephen J Ruskewicz

James R Casciani

Paul David Mannheimer

Steve L Nierlich

Haakon T Magnussen, Jr

Gary L Smith

Anthony K Wingo

Kenneth Rainin

Haakon T Magnussen

Phillip S Palmer

Steven L Nierlich

Magnussen, Jr Haakon T

Mitch Levinson

A pulse oximeter sensor with a light source optimized for low oxygen saturation ranges and for maximizing the immunity to perturbation induced artifact. Preferably, a red and an infrared light source are used, with the red light source having a mean wavelength between 700-790 nm. The infrared light source can have a mean wavelength as in prior art devices used on patients with high saturation. The sensor of the present invention is further optimized by arranging the spacing between the light emitter and light detectors to minimize the sensitivity to perturbation induced artifact. The present invention optimizes the chosen wavelengths to achieve a closer matching of the absorption and scattering coefficient products for the red and IR light sources. This optimization gives robust readings in the presence of perturbation artifacts including force variations, tissue variations and variations in the oxygen saturation itself.

Pulse oximeter and sensor optimized for low saturation

Oximeter with selection between calculations based on patient type

Embodiments of the present invention are directed to a system and method for measuring blood oxygen saturation. Specifically, embodiments of the present invention include emitting light having a wavelength spectrum that is optimized for an oxygen saturation reading less than 80 percent, detecting the light, and transmitting signals based on the detected light, the signals being useful in determining blood oxygen saturation with a pulse oximeter.

The invention provides a triggering mechanism for actuating a trigger signal in response to a pre-determined rate of fluid flow through the mechanism. Triggering mechanism generally includes a sliding piston within an air channel, held in place by a resistance structure. Further provided are aerosol delivery devices having triggering mechanism.

Fluid velocity-sensitive trigger mechanism

Devices for the generation of inhalable aerosols by extrusion through a porous membrane by a motor-driven cam assembly are disclosed. The device holds a drug formulation container in a drug release position. The package is comprised of a collapsible wall with an opening and a cover for the opening that includes a porous membrane having a plurality of pores therein with a diameter in the range of 0.5 to 6.0 microns. An electric motor in the device is powered by a battery to rotate a cam assembly having three cams. The first cam forces a clamping member (configured to correspond to the outer periphery of the container) against the periphery of the collapsible wall of the container, sealing the jointure of the collapsible wall to the cover of the container along the entire periphery, except for a small unsealed portion thereof. The second cam crushes the collapsible wall, forcing the contents of the container through the unsealed portion of the jointure. The third cam operates to move the empty container out of the drug release position, while moving a new container into position.

Aerosol extrusion mechanism

An oximeter sensor formed with a housing made of a relatively rigid material into which the oximeter electrical components can be mounted is provided. An overmolded material, of lesser rigidity, is injection-molded over the housing to complete the sensor. In one embodiment the housing is made of plastic, such as polypropylene, and the overmolded material is an injection-molded thermal plastic elastomer, such as Santoprene.TM. (polypropylene with 1 micron size particles of rubber). The housing preferably contains thin portions connecting thicker portions which support the electrical and optical components. These thin portions provide natural bending portions in the final oximeter sensor. By having the thin portions near or at the central, neutral axis of the sensor, flexibility is optimized in the longitudinal direction, while the housing provides stiffness laterally.

Oximeter sensor with rigid inner housing and pliable overmold

A pulse oximeter sensor with a light source optimized for low oxygen saturation ranges and for maximizing the immunity to perturbation induced artifact. Preferably, a red and an infrared light source are used, with the red light source having a mean wavelength between 700-790 nm. The infrared light source can have a mean wavelength as in prior art devices used on adults. The sensor of the present invention is further optimized by arranging the spacing between the light emitter and light detectors to minimize the sensitivity to perturbation induced artifact. The present invention optimizes the chosen wavelengths to achieve a closer matching of the absorption and scattering coefficient products for the red and IR light sources. This optimization gives robust readings in the presence of perturbation artifacts including force variations, tissue variations and variations in the oxygen saturation itself.

Pulse oximeter sensor optimized for low saturation

The present invention provides a method and apparatus for improved fetal contact with a fetal probe. The easily insertable probe includes a means for adjusting the position of the probe so that a sensor makes firm contact with the fetus. In one embodiment, the position is adjusted via a biasing segment of the probe which rotates about a fulcrum. In another embodiment, the position is adjusted via a bladder.

Method and apparatus for improved fetus contact with fetal probe

A hand held self-contained automated pipette for portable operation having an electrically operated digital linear actuator. The actuator preferably includes a stepper motor driving a rotor. A threaded screw is coaxially positioned within the rotor and is connected to an actuator shaft having elongate grooves slidable in a guide for preventing shaft rotation so that precise linear motion is imparted to the shaft. A pipetting displacement assembly having one of various sizes is removably attached for actuation by a common actuator including programmed movement of a displacing piston in a displacement cylinder to optimize air interface volume, neutralize variations in vacuum pipette effects, and provide an accommodated stroke and readout for improved accuracy while pipetting and/or titrating different ranges of volumes. Upon calibration the piston undertakes immediate excursion to an end of travel limit and after motor slippage is retracted to a home position. This home position is chosen for optimum preservation of an air interface volume between drawn liquid and the piston tailored with particularity to the displacement assembly being used. Multiple precision modes, including pipetting, multiple dispensing, titration, dilution, and measurement, are provided.

Method for dispensing liquids with a pipette with compensation for air

A hand held self-contained automated pipette for portable operation having an electrically operated digital linear actuator. The actuator preferably includes a stepper motor driving a rotor. A threaded screw is coaxially positioned within the rotor and is connected to an actuator shaft having elongate grooves slidable in a guide for preventing shaft rotation so that precise linear motion is imparted to the shaft. A pipetting displacement assembly having one of various sizes is removably attached for actuation by a common actuator including programmed movement of a displacing piston in a displacement cylinder to optimize air interface volume, neutralize variations in vacuum pipette effects, and provide an accommodated stroke and readout for improved accuracy while pipetting and/or titrating different ranges of volumes. Upon calibration the piston undertakes immediate excursion to an end of travel limit and after motor slippage is retracted to a home position. This home position is chosen for optimum preservation of an air interface volume between drawn liquid and the piston tailored with particularity to the displacement assembly being used. Multiple precision modes, including pipetting, multiple dispensing, titration, dilution, and measurement, are provided. Other features are also disclosed.

Portable automated pipette for accurately pipetting and/or titrating

An enclosed pipette tip rack utilizing a container having a bottom and a side portion connected to the bottom which extends upwardly and terminates in a top. A tray is supported by the container and holds at least one pipette tip such that a portion of the pipette tip lies within the container. A cover is also included and is supported by the container adjacent the tray. The container and cover are vented to the ambient environment.

Growing community of inventors

Kensington, CA, United States of America

Stephen J Ruskewicz