Elan Pharmaceuticals, Inc.

Stephen J Karlik

Andrei William Konradi

Michael A Pleiss

Christopher Michael Semko

Darren B Dressen

Stephen B Freedman

Ted A Yednock

Francine S Farouz

Elizabeth Messersmith

The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti-inflammatory agents used to palliate conditions and diseases associated with demyelination.

Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents

Growing community of inventors

CA

Stephen J Karlik