Warner-lambert Company

Stephen J Johnson

Lawrence D Wise

David Juergen Wustrow

Suzanne Ross Kesten

Jonathan L Wright

Dennis M Downing

David T Connor

Paul C Unangst

Juan C Jaen

Bradley W Caprathe

Steven Robert Miller

William J Smith, Iii

David Christopher Horwell

Walter H Moos

Om Prakash Goel

Shelly Ann Glase

Sheila H Hobbs

Leonard Theodore Meltzer

This invention provides 6-amino-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one oximes and hydrazones which are useful in treating Parkinson's disease.

Hexahydro-naphthalenone oximes and hydrazones

This invention relates to compounds that are antagonists of dopamine D4 receptors, and to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4 receptors.

Compounds and method of treating psychosis and schizophrenia

Amino acid complexes of cobalt (III) mesoporphyrin IX and cobalt (III)

This invention relates to compounds that are antagonists of dopamine D4 receptors, to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4 receptors, and to pharmaceutically acceptable compositions that contain a dopamine D4 receptor antagonist.

Coumarin dopamine D4 receptor antagonists

Benzimidazoles and imidazopyridines are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and for the treatment of disorders which respond to dopaminergic blockade including psychotis depression, substance abuse, and compulsive disorders.

Benzimidazoles and imidazopyridines as central nervous system agents

Neurotensin antagonists are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and as agents to treat Parkinson's disease and gastrointestinal disorders.

Neurotensin antagonists

1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.

1,3-substituted cycloalkenes and cycloalkanes as central nervous system

Oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones substituted in the 4-position of the oxazolidin-2-one ring and the 3-position of the 1,2,4-oxadiazolin-5-one ring with a 5- or 6-member heteroaromatic, a bicyclic heteroaromatic group or a 5- or 6-member heterocyclic group either directly or via a one or two carbon bridge and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetycholine production or release.

Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and

(S)-3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)-methyl]-2-oxazolidinone or a pharmaceutically acceptable salt thereof is useful in the treatment of the symptoms of cognitive decline in an elderly patient suffering therefrom including the treatment of Alzheimer's disease.

Method of treating the symptoms of cognitive decline in an elderly

Certain 1,2-diamino-4,5-dimethoxycyclohexane amide derivatives have analgesic activity, and bind selectively to the kappa opioid receptor site. Pharmaceutical compositions containing these compounds, and a method of alleviating pain in mammals are also disclosed.

Growing community of inventors

Ann Arbor, MI, United States of America

Stephen J Johnson