Harvard College

Stephen J Devience

Matthew Scot Rosen

Ronald Lee Walsworth

Methods and systems for Nuclear Magnetic Resonance (NMR) spectra of samples having unresolved peaks are described. The methods and systems allow for the creation nuclear spin singlet states in nearly-equivalent spin pairs, for example, using continuous spin-locking with a nutation frequency matched to the coupling strength between spins. The invention relates generally to the field Nuclear Magnetic Resonance (NMR). Nuclear magnetic resonance (NMR) spectroscopy can be used as a tool for determining the chemical structure and/or geometry of a molecule in a sample. In many samples, however, resonance frequencies of different nuclei fully or partially overlap, which makes chemical identification of molecule(s) in a sample difficult or impossible.

Creation of nearly-equivalent nuclear spin singlet states using spin-lock induced crossing

Methods and systems for Nuclear Magnetic Resonance (NMR) spectra of complex chemical mixtures are described. The methods and systems allow undesired NMR spectral background to be removed or suppressed and target spectral peaks to be uncovered, for example, when strong background signals overlap weaker peaks. In some embodiments, the methods and systems employ a quantum filter utilizing nuclear spin singlet states.

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Cambridge, MA, United States of America

Stephen J Devience