The United States of America, As Represented by the Secretary, Department of Health and Human Services

Stephen J Demosky

Alan Thomas Remaley

John A Stonik

Edward B Neufeld

Fairwell Thomas

H Bryan Brewer

Marcelo J A Amar

Marcele J A Amar

Bryan H Brewer

Marcele J Amar

H Brewer

Disclosed herein are peptides or peptide analogs with multiple amphipathic &#x3b1;-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic &#x3b1;-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.

Multi-domain amphipathic helical peptides and methods of their use

Method of treating or inhibiting inflammation by multi-domain amphipathic helical peptides

Isolated nucleic acid molecule encoding a peptide or peptide analog comprising the SEQ ID No. 3

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Gaithersburg, MD, United States of America

Stephen J Demosky