Advanced Cardiovascular Systems, Inc.

Stephen J Bigus

Eugene T Michal

Christopher J Buchko

Deborah L Kilpatrick

Steven B Choi

Dorrie M Happ

Virgilda Torate

Phebe T Cababaro

A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.

Therapeutic, diagnostic, or hydrophilic coating for an intracorporeal medical device

The catheter assembly includes an expandable member mounted to the distal end of a placement catheter, for delivery of a therapeutic device in one of the branch vessels of a bifurcated vessel. The catheter assembly includes lumens for a tracking guide wire and a positioning guide member for placement of the therapeutic device. The therapeutic device is mounted on the expandable member, the tracking guide wire is placed into the target branch vessel, and the placement catheter is then introduced over the tracking guide wire. A positioning guide member is introduced through the catheter, extended through an exit port in the catheter proximal to the expandable member, and then placed in another branch vessel of the bifurcation. The placement catheter then is advanced until the positioning guide member engages the vessel carina between the branch vessels, and the therapeutic device then may be placed accurately in the target branch vessel. In another form of the catheter assembly, a secondary catheter member is mounted to the placement catheter and adapted to receive the positioning guide member for placement of the positioning guide member in the vessel branch not to be treated. An elongated angle member is mounted to the secondary catheter member for engagement with the vessel carina.

Catheter for placement of therapeutic devices at the ostium of a bifurcation of a body lumen

An intraluminal catheter having a catheter shaft and distal member rotatable relative to at least a section of the catheter shaft. In one embodiment, the catheter has a catheter shaft, a distal member, which in a presently preferred embodiment is a balloon mounted on a distal portion of the shaft, and a tubular sealing member having an expandable portion disposed at least in part within a section of the distal member. The tubular sealing member has an expanded configuration, and an unexpanded configuration expandable into contact with the section of the distal member, so that the distal member is rotatable relative to at least a section of the catheter shaft and to the tubular sealing member when the tubular sealing member is in the unexpanded configuration.

Catheter with rotatable balloon

A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a top coat having a therapeutic, diagnostic or hydrophilic agent, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of an agent, a grafting component, and salt. In one embodiment, the therapeutic agent is superoxide dismutase or a superoxide dismutase mimic. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device such as a stent coated with a polymeric primer or without a primer.

Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device

A method of providing a lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable and highly lubricious when in contact with body fluids. In one embodiment, the coating comprises a polymerized base coat and a hydrophilic top coat, where the base coat has a binding component which binds to the hydrophilic compound of the top coat, and a grafting component which binds to the binding component and to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The hydrophilic coating of the invention can be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer.

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San Jose, CA, United States of America

Stephen J Bigus