Echelon Diagnostics, Inc.

Other

Biotique Systems, Inc.

Stephen Healy Sanders

John P Burke

Michael Rogoff

Techniques for measuring abundances of sequences includes obtaining first data that indicates a target sequence at a plurality of loci, wherein the target sequence comprises a plurality of bins of loci for which a relative abundance is indicative of a condition of interest. Second data is determined that indicates alignment with the target sequence of reads of DNA fragments in a sample from the subject. Third data is determined that indicates locus dependent observed variations in abundance. A raw count Hj of reads is determined that start at each locus j; and, a copy number of a first bin is determined based on a sum over all loci in the first bin of expected counts for each partition weighted by the locus dependent observed variations. Output data that indicates condition of the subject based at least in part on the copy number of the first bin is presented.

System for increasing the accuracy of non invasive prenatal diagnostics and liquid biopsy by observed loci bias correction at single base resolution

A method and apparatus for automatically determining a characteristic of a crop using an unmanned aerial vehicle (UAV) includes operating the UAV at an elevation above a ground surface of a field and collecting first data that indicates an elevation of the UAV with a barometric pressure based altimeter of the UAV. Second data is collected with a SONAR sensor of the UAV that indicates a distance to a nearest object on the ground surface. The SONAR sensor has a SONAR sensor range and the elevation above the ground surface is less than the SONAR sensor range. The method further includes receiving the first data and the second data on a processor, and determining a height of the nearest object above the ground surface with the processor based on the first data and second data. Output data that indicates the height of the nearest object is presented on a display.

System and method for automatically determining crop characteristics using unmanned aerial vehicle (UAV)

Techniques for construction of internal controls for improved accuracy and sensitivity of DNA testing include obtaining first data and determining weights over real numbers for a normalization function in less than a day. The first data indicates a measured amount of reference sequences for nucleic acids from training samples. The reference sequences include a target, for which an abundance is indicative of a condition of interest, and covariates not correlated with the condition of interest. The normalization function involves a sum of abundances of the covariates, as internal controls, each multiplied by a corresponding one of the weights. The weights are determined based on minimizing variance of a Taylor expansion of a ratio of a measured amount of the target divided by a value of the normalization function evaluated with measured amounts of the covariates over a portion of the first data in which the condition is absent.

System and method for construction of internal controls for improved accuracy and sensitivity of DNA testing

A leaf collecting and bagging assembly is made up of flexible plastic sheet having a draw string along its perimeter and capable of being spread out on the ground to serve as a leaf collecting surface and then converted into a bag by drawing the draw string to contain the leaves for discarding along with the bag.

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Reno, NV, United States of America

Stephen Healy Sanders