Cambridge Polymer Group, Inc.

The General Hospital Corporation

Massachusetts General Hospital Corporation

Zimmer Gmbh

The General Hosital Corporation

The General Hospital Corporation D/b/a Massachusetts General Hospital

Stephen H Spiegelberg

Orhun K Muratoglu

Gareth H McKinley

Jeffrey W Ruberti

Niels Alexander Abt

Gavin J C Braithwaite

Steven Charlebois

Brian H Thomas

Donald L Yakimicki

Gavin Braithwaite

Hatice Bodugoz-Senturk

Jeeyoung Choi

James Mason

Orthun K Muratoglu

Gavin G C Braithwaite

H Massachusetts Gen Hospital Bodugoz-Senturk

Gavin JC Braithwaite

Gareth H Mckinley

The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.

Methods for making oxidation resistant polymeric material

The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.

Cross-linking of antioxidant-containing polymers

The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.

The invention provides fabricated tough hydrogels, hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the tough hydrogels, or the hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making crosslinked tough hydrogels, and crosslinked tough hydrogel-containing compositions also are disclosed herein.

Tough hydrogels

Various embodiments of mosaicplasty constructs and methods for implanting the constructs into anatomical structures. The mosaicplasty constructs may be formed from artificial materials and may include a hard articulating portion and a relatively softer elastic, support portion. The mosaicplasty constructs may include bone ingrowth materials to facilitate ingrowth of bone and other tissues into the construct. The mosaicplasty constructs may also be at least partially formed of hydrogel materials.

Mosaicplasty constructs

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Winchester, MA, United States of America

Stephen H Spiegelberg