Amgen Inc.

Stephen Foster

Ian Nevin Foltz

Randal Robert Ketchem

Douglas Pat Cerretti

Christopher Mehlin

Xiao Feng

James F Smothers

Xiao-Dong Yang

Kenneth Allan Brasel

Sharon Wong-Madden

Jilin Sun

Brian Gliniak

Alison Fitch

Randall R Ketchem

Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand ('TRAIL') Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.

TRAIL receptor-2 polypeptides and antibodies

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Newbury Park, CA, United States of America

Stephen Foster