Guardant Health, Inc.

Stephen Fairclough

Darya Chudova

Andrew Kennedy

Marcin Sikora

Ariel Jaimovich

Sequencing nucleic acids can identify variations associated with presence, susceptibility or prognosis of disease. However, the value of such information can be compromised by errors introduced by or before the sequencing process including preparing nucleic acids for sequencing. Blunting single-stranded overhangs on nucleic acids in a sample can introduce deamination-induced sequencing errors. The disclosure provides methods of identifying and correcting for such deamination-induced sequencing errors and distinguishing them from real sequence variations.

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Redwood City, CA, United States of America

Stephen Fairclough