Other

Itherx Pharmaceuticals Inc.

Microsoft Technology Licensing, LLC

Smithkline Beecham Corporation

Ligand Pharmaceuticals, Inc.

Kemia, Inc.

Stephen F Miller

Juan I Luengo

Robert W Sullivan

Kevin J Duffy

Antonio Garrido Montalban

Justin T Ernst

Edward Roberts

Christopher Larson

Russell Dahl

Hiroshi Nakanishi

Alcinda Miller

Jeffrey Dean Kahl

Andrey Zykin

Nancy G J Delaet

Eddine Saiah

Zhinjun Wang

Erik Boman

Susana Conde Ceide

John G Gleason

Kristofer Noel Iverson

Antony N Shaw

Eric David Heutchy

Bryan Trussel

Julian Jenkins

Jan Urban

Kent Pryor

Nancy Delaet

Alan T Price

Jeremy Mercer

Lubomir Sebo

A new method, system and apparatus for mounting mechanically, thermally and electrically light emitting diode (LED), crystals, arrays or packages. The above provides an LED assembly having reduced number of components and costs, superior heat dissipation, mechanical properties and a compact structure. The use of a grid or mesh allows for more efficient and inexpensive removal of heat from one or more LEDs within an LED fixture.

LS grid core LED connector system and manufacturing method

A system includes a server and a source client executable on a first electronic device in communication with the server The server is configured to provide to a second electronic device in communication with the server access to location data implementable by a user interface associated with the second electronic device The location data enables the user interface to display the geographical location of the first electronic device The access to the location data is accessible to the second electronic device only during a time interval designated by a user of the first electronic device.

Sharing of location information in a networked computing environment

The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.

Cytokine inhibitors

A collapsible support structure comprises a plurality of interconnected substantially triangular frame sections connected by flexible joints at corners thereof. At least some of the interconnected frame sections share a collapsible tubular member as one side of the interconnected triangular frame sections and at least some of the ends of rigid tubular members of the interconnected frame sections are disposed between adjacent shared collapsible tubular members. An elongated flexible tensioning member extends through the shared collapsible tubular members and between the ends of the rigid tubular members disposed between adjacent shared collapsible tubular members. The rigid tubular members of some of the interconnected frame sections form a frame roof with ends thereof tied to form a flexible joint at the apex frame roof.

Collapsible Support Structure

A game or other software program is made accessible for execution by clients on a peer-peer network only after a plurality of verifications are made to ensure that control of the software is maintained. With a request sent to a server to access the software, a client includes a nonce and an ID of the user. The server digitally signs a portion of a ticket that is returned to the client, which includes the nonce, a time stamp, and the ID. The ticket is required to access the software. The clients are required to exchange the tickets, verify the digital signature on the portion of each ticket, and use the information therein to confirm that the tickets are current, issued by the correct server, issued to the proper users, and received from the users who are intended to execute the software.

Trial-before-purchase subscription game infrastructure for peer-peer networks

An apparatus and method is disclosed for providing a collapsible support structure strut, which may include a strut member; a hollow tubular terminal end portion of the strut member having an inner surface; and a detachable looped eyelet having at least one loop and a pair of extending legs, the legs being springedly biased to engage the tubular terminal end of the strut, thereby frictionally holding the looped eyelet in place at the terminal end of the strut. The apparatus and method may also employ a holding plug, with first and second holding groove opposingly placed in the periphery of the holding plug, having at least a portion thereof that is shaped and sized to frictionally engage the inner surface of the tubular terminal end of the strut, to frictionally hold the holding plug in engagement with the strut. The detachable looped eyelet may also have at least two loop.

Collapsible structural frame

In various aspects, the present invention relates to non-peptidic compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of some such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone diseases and metabolic diseases.

Modulators of calcitonin and amylin receptor activity

Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thiosemicarbazone derivative.

Thrombopoietin mimetics

An apparatus and method is disclosed for providing a collapsible support structure strut, which may include a strut member; a hollow tubular terminal end portion of the strut member having an inner surface; and a detachable looped eyelet having at least one loop and a pair of extending legs, the legs being springedly biased to engage the tubular terminal end of the strut, thereby frictionally holding the looped eyelet in place at the terminal end of the strut. The apparatus and method may also employ a holding plug, with first and second holding groove opposingly placed in the periphery of the holding plug, having at least a portion thereof that is shaped and sized to frictionally engage the inner surface of the tubular terminal end of the strut, to frictionally hold the holding plug in engagement with the strut. The detachable looped eyelet may also have at least two loops.

Non-peptide TPO mimetics are disclosed, as well as a method of treating thrombocytopenia, in a mammal, including a human, in need thereof, which comprises administering to such mammal an effective amount of a selected hydroxy-1-azo-naphthalene derivative.

Dimeric cell-surface receptors in a subject are agonized by administering a metal chelated dimeric cell-surface receptor ligand formed by chelating a receptor binding moiety with a metal ion such as zinc, or by co-administering the receptor binding moiety and the metal ion. The binding moiety is a small organic molecule having a molecular weight of from about 100 to about 850, and metal chelation may form a symmetrical multimer such as a dimer of the receptor binding moiety. An example is bis&lcub;2,5-bis&lsqb;2-benzimidazolylimino&rsqb;-3a,6a-bis(2-pyridyl)-1,2,3,3a,4,5,6,6a-octahydroimidazo&lsqb;4,5-d&rsqb;imidazole-N,N&prime;&rcub;-zinc(II). Dimeric cell surface receptors include granulocyte colony-stimulating factor, erythropoeitin receptor, macrophage-colony-stimulating factor, growth hormone receptor, thrombopoietin receptor, interferon alpha receptor, interferon beta receptor, tyrosine kinase receptor, insulin receptor and leptin receptor. A pharmaceutical composition containing a carrier and the ligand or the binding moiety and the metal ion separately can be used to enhance leukocyte production and to treat bacterial and fungal infections.

Agonizing dimeric cell-surface receptors with a receptor binding moiety and chelating metal

Growing community of inventors

Laguna Beach, CA, United States of America

Stephen F Miller