Sanofi Pasteur Biologics, LLC

Sanofi Pasteur Inc.

Genentech, Inc.

Stephen F Anderson

Mark Zoller

David Botstein

Nicholas F Paoni

William F Bennett

Deborah L Higgins

Simon Delagrave

Sophia Mundle

Harold Kleanthous

Pierre Garrone

Nicola Beltraminelli

Jianxin Zhang

Natalie Anosova

Majid Mehtali

John Hamberger

Nausheen Rahman

Qinglian Li

The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at least two or more pharmaceutically acceptable excepients, at least one of which is histidine and at least one of which is a sugar or sugar alcohol. The compostions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.

Herpesvirus compositions and related methods

Monoclonal antibodies, or antigen-binding fragments thereof, that bind to() toxin A or toxin B and methods of using the same to detect or treatinfections and/or-associated disease.

Antibodies against clostridium difficile toxins and methods of using the same

The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at least two or more pharmaceutically acceptable exctpients, at least one of which is histidine and at least one of which is a sugar or sugar alcohol. The compositions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.

The present disclosure provides a method to prepare purified enveloped viral particle preparations employing ion exchange chromatography and tangential flow filtration.

Purification of herpes virus

Antibodies againsttoxins and methods of using the same

Monoclonal antibodies or antigen-binding fragments thereof, that bind to() toxin A or toxin B and methods of using the same to detect or treatinfections and/or-associated disease.is a gram positive, anaerobic bacterium that causes gastrointestinal disease in humans. The bacteria are transmitted through feces and spread to food and other surfaces when people who are infected do not thoroughly wash their hands.

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Arlington, MA, United States of America

Stephen F Anderson