Biogen Idec Ma Inc.

Stephen E Fawell

James G Barsoum

Matthew B Jarpe

Steven Donald Miklasz

Brian A Elenbaas

Michael Parr

The invention provides methods and compositions for increasing the delivery of nucleic acids into a host by administering a nucleic acid encoding a therapeutic nucleic acid along with an agent that modulates Kupffer cell function in the host.

Method of enhancing delivery of a therapeutic nucleic acid

This invention provides antibodies to the prolactin receptor, particularly the human prolactin receptor. Preferred antibodies are capable of blocking prolactin binding to the prolactin receptor, inhibiting signaling through the prolactin receptor, and/or inhibiting proliferation of cancer cells induced by prolactin. Also provided are nucleic acids encoding the antibodies, vectors and host cells comprising the nucleic acids, and uses of the antibodies and nucleic acids.

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Framingham, MA, United States of America

Stephen E Fawell