Koninklijke Philips Corporation N.v.

Ric Investments, Inc.

Stephen Dalton Pittman

Erik Kurt Witt

Douglas M Mechlenburg

Stefanida K Blake

Charles Thomas

Smita Garde

Lauren Elizabeth Hueser

Leonardo A Baloa

David Harrell

Jacobo D Reif

David P White

Manuel Laura

Jacobo Reif

An interface appliance is configured to deliver a flow of fluid to the airway of a subject. The generation of the flow of fluid may be controlled to provide a therapeutic benefit to the subject. The interface appliance is configured to carry one or more sensors () configured to detect one or more parameters related to the flow of fluid on the subject. The one or more parameters may then be used to control the generation and/or delivery of the flow of fluid.

Interface appliance carrying one or more sensors detecting parameters related to a flow of fluid delivered through the appliance

A system and method are configured to adjust the tidal volume of the breathing of a subject. The subject is self-ventilating (breathes under her own power). The adjustment of tidal volume accomplished through use of the system and/or method may reduce hypertension (e.g., lower blood pressure), reduce stress and/or anxiety (and related maladies), improve relaxation, decrease sleep latency, improve sleep quality, address other sleep disorders, and/or provide other health benefits. The system and method are effective in adjusting tidal volume while the subject is awake and/or asleep.

System and method for adjusting tidal volume of a self-ventilation subject

A pressurized flow of breathable gas is delivered to the airway of a subject through a gas circuit () as part of a therapy regime. Leakage of gas from within the circuit to atmosphere to prevent re-breathing of gas is dynamically adjusted to stabalize the total amount of leakage.

System and method for controlling leakage of a circuit delivering a pressurized flow of breathable gas to a subject

A system that determines one or more sleep phenotyping parameters of a subject. In one embodiment, the system comprises a sleep sensor, a stimulus generator, and a processor. The sleep sensor generates signals that convey information related to the physiological functions that indicate the sleep stage of the subject. The stimulus generator provides a stimulus to the subject that enables information related to the sleep phenotyping parameters to be determined. The processor receives the signals generated by the sleep sensor and is in operative communication with the stimulus generator. The processor (i) determines, based on the signals received from the sleep sensor, whether a trigger condition related to the current sleep stage of the subject is satisfied, (ii) controls the stimulus generator to provide the stimulus to the subject if the trigger condition is satisfied, and (iii) quantifies the response of the subject to the stimulus.

Automated sleep phenotyping

A therapy system adapted to treat a patient's ventilatory instability using a ventilatory therapy, a gas modulation therapy, or both. The algorithm implemented by the therapy system monitors the ventilatory instability, such as Cheyne Stokes Respiration (CSR), mixed apneas, CPAP emergent apneas, and complex sleep disordered breathing (CSDB) and treats the ventilatory instability. The algorithm also determine a reference point with respect to the ventilatory instability. The therapy delivery system initiate the treatment based on the reference point.

System and method for treating ventilatory instability

A system is provided for delivering a flow of breathing gas to an airway of a patient. The system includes a pressurizing flow module that generates a pressurized flow of breathing gas and a patient circuit coupled to the pressurizing flow module configured to communicate the flow of breathing gas to an airway of a patient. The system includes a sensor for monitoring a characteristic of a breathing pattern of the patient a controller that communicates with the sensor configured to increase a fraction of inspired carbon dioxide if the characteristic exceeds an upper threshold value and to provide servo-ventilation if the characteristic is less than a lower threshold value. The upper threshold value and the lower threshold value are changed based on the monitored characteristic of the breathing pattern of the patient.

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Brookline, MA, United States of America

Stephen Dalton Pittman