The Public Health Research Institute of the City of New York, Inc.

Ambi Inc.

Applied Microbiology, Inc.

Peter Blackburn

Stephen D. Rubino

June Polak

Sara-Ann Gusik

Stephen D Rubino

Bacteriocin compositions comprising lanthionine containing bacteriocins and non-bactericidal agents. When the bacteriocin compositions are combined with a suitable carrier with each component present in sufficient quantities such that the composition is effective against Gram negative bacteria in addition to Gram positive bacteria, they become enhanced, rapid acting, broad range bactericides suitable for a variety of applications.

Nisin compositions for use as enhanced, broad range bactericides

Nisin compositions for use as enhanced broad range bactericides

Broad range bacteriocin compositions are provided. The compositions can be dissolved or suspended in a suitable solvent or matrix and are more active towards a broader range of bacteria than are any of the component parts. The dissolved or suspended compositions constitute enhanced broad range bactericides. The compositions include lysostaphin and a lanthionine containing peptide bacteriocin; lysostaphin, a lanthionine containing peptide bacteriocin and a chelating agent; and lysostaphin, a lanthionine containing peptide, a chelating agent and a surfactant. Each component is present in the enhanced broad range bactericide in sufficient amount such that the bactericide is more effective against staphylococci than is lysostaphin alone and is more effective at treating and preventing a broad range of microbial infections. Methods of treating bacterial infections using said compositions and bactericides are provided.

Novel bacteriocin compositions for use as enhanced broad range

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New York, NY, United States of America

Stephen D Rubino