Clinical Micro Sensors, Inc.

Nanostream, Inc.

Osmetech Technology, Inc.

California Institute of Technology

Osmetch Technology, Inc.

Clinical Micro Systems, Inc.

Stephen D O'Connor

Jon Faiz Kayyem

Thomas J Meade

Christoph D Karp

Eugene Dantsker

Changjun Yu

Michael Gozin

Marci Pezzuto

Gary Fife Blackburn

Robert H Terbrueggen

Steven E Hobbs

Paren P Patel

Gary T Olsen

Hau H Duong

Scott E Fraser

Ronald C Gamble

Jost G Vielmetter

Bruce D Irvine

John D Baldeschwieler

Matthew M Gregori

Thomas W Welch

Stephen E Creager

Robert Pietri

Marc Alexander Unger

Frederic Zenhausern

Piotr Grodzinski

Jeffrey Alan Koehler

Jesse L Beauchamp

Schubert Francis Soares

Joseph F Covington

Dmitri A Kossakovski

Adrian Hightower

Mike S Lee

David Randall Baselt

Scott G Beach

Vincent K Gustafson

Daniel A Litvack

Javier Gonzalez

Marcel Widmer

Bruce Wilcox

Surekha Vajjhala

Courtney Coyne

The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.

Electronic methods for the detection of analytes

Electronics method for the detection of analytes

The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.

Compositions for the electronic detection of analytes utilizing monolayers

The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

Electrodes linked via conductive oligomers to nucleic acids

AC/DC voltage apparatus for detection of nucleic acids

Electrodes linked via oligomers to nucleic acids

The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.

Devices and methods for biochip multiplexing

Chromatographic separation devices include multiple batch-processed columns joined by a body structure and adapted to perform parallel analyses. Both slurry-packed and monolithic column embodiments are provided. One or more liquid-permeable frits of various types may be used to retain stationary phase material within columns. A fluidic distribution network may be used to distribute stationary phase material and/or mobile phase solvents to multiple columns. Separation devices, including microfluidic embodiments, may be fabricated with various materials including polymers. Multi-column fabrication and separation methods are provided.

Multi-column separation devices and methods

The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.

Growing community of inventors

Pasadena, CA, United States of America

Stephen D O'Connor