Gilead Sciences, Inc.

Carna Biosciences, Inc.

Stephen D Holmbo

Leena Patel

Heath A Weaver

Michael Graupe

Juan A Guerrero

Tetsuya Kobayashi

Suet Chung Yeung

Jie Xu

Yasamin Moazami

Jesse M Jacobsen

Julian Andrew Codelli

Qingming Zhu

Kevin S Currie

Jennifer Anne Treiberg

Seung H Lee

Jonathan William Medley

Stephane Perreault

Jayaraman Chandrasekhar

Masaaki Sawa

Patrick J Salvo

Hirokazu Matsumoto

Mai Arai

Ryoko Nakai

Catherine Pugh

Thomas J Paul

David L Kukla

Jonah J Chang

Will Watkins

Latesh Lad

Eric Hu

Provided herein is a compound of Formula I: or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, a pharmaceutical composition comprising a compound of the present invention, together with a pharmaceutically acceptable excipient thereof, and a method of treating cancer with the same.

PARP7 inhibitors

The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Diacylglycerol kinase modulating compounds

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Kirkland, WA, United States of America

Stephen D Holmbo