Health Discovery Corporation

Biowulf Technologies, LLC

Barnhill Technologies LLC

Horus Therapeutics, Inc.

Stephen D Barnhill

Isabelle Guyon

Jason Edward Weston

Zhen Zhang

Hong J Zhang

Garry Carls

Ramananda Madyastha

A system and method are provided for diagnosing diseases or conditions from digital images taken by a remote user with a smart phone or a digital camera and transmitted to an image analysis server in communication with a distributed network. The image analysis server includes a trained learning machine for classification of the images. The user-provided image is pre-processed to extract dimensional, shape and color features then is processed using the trained learning machine to classify the image. The classification result is postprocessed to generate a risk score that is transmitted to the remote user. A database associated with the server may include referral information for geographically matching the remote user with a local physician. An optional operation includes collection of financial information to secure payment for analysis services.

System and method for remote melanoma screening

A network-based system is provided for performing data analysis services using a support vector machine for analyzing data received from a remote user connected to the network. The user transmits a data set to be analyzed and along with an account identifier that allows the analysis service provider to collect payment for the processing services. Once payment has been confirmed, the service provider's server transmits the analysis results to the remote user.

System for providing data analysis services using a support vector machine for processing data received from a remote source

A computer system for performing data analysis services using a support vector machine for analyzing data received from a remote source on a distributed network includes a server in communication with the distributed network for receiving a data set and a financial account identifier associated with the remote source. The server communicates over the distributed network with a financial institution to receive funds from a financial account identified by the financial account identifier. A processor receives one or more data sets from the remote source and pre-processes the data to enhance meaning within the data set. The pre-processed data is used to train and test a support vector machine for recognizing patterns within the data. Live data is processed using the trained and tested support vector machine to generate an output which is transmitted to the remote source after the server confirms that payment for the data processing service has been received.

Identification of a determinative subset of features from within a large set of features is performed by training a support vector machine to rank the features according to classifier weights, where features are removed to determine how their removal affects the value of the classifier weights. The features having the smallest weight values are removed and a new support vector machine is trained with the remaining weights. The process is repeated until a relatively small subset of features remain that is capable of accurately separating the data into different patterns or classes. The method is applied for selecting the smallest number of genes that are capable of accurately distinguishing between medical conditions such as cancer and non-cancer.

Feature selection method using support vector machine classifier

Digitized image data are input into a processor where a detection component identifies the areas (objects) of particular interest in the image and, by segmentation, separates those objects from the background. A feature extraction component formulates numerical values relevant to the classification task from the segmented objects. Results of the preceding analysis steps are input into a trained learning machine classifier which produces an output which may consist of an index discriminating between two possible diagnoses, or some other output in the desired output format. In one embodiment, digitized image data are input into a plurality of subsystems, each subsystem having one or more support vector machines. Pre-processing may include the use of known transformations which facilitate extraction of the useful data. Each subsystem analyzes the data relevant to a different feature or characteristic found within the image. Once each subsystem completes its analysis and classification, the output for all subsystems is input into an overall support vector machine analyzer which combines the data to make a diagnosis, decision or other action which utilizes the knowledge obtained from the image.

Computer-aided image analysis

Systems and methods for enhancing knowledge discovery from data using multiple learning machines in general and multiple support vector machines in particular. Training data for a learning machine is pre-processed in order to add meaning thereto. Multiple support vector machines, each comprising distinct kernels, are trained with the pre-processed training data and are tested with test data that is pre-processed in the same manner. The test outputs from multiple support vector machines are compared in order to determine which of the test outputs if any represents a optimal solution. Selection of one or more kernels may be adjusted and one or more support vector machines may be retrained and retested. Optimal solutions based on distinct input data sets may be combined to form a new input data set to be input into one or more additional support vector machine. The methods, systems and devices of the present invention comprise use of Support Vector Machines for the identification of patterns that are important for medical diagnosis, prognosis and treatment. Such patterns may be found in many different datasets. The present invention also comprises methods and compositions for the treatment and diagnosis of medical conditions.

Methods of identifying biological patterns using multiple data sets

A learning machine is used to extract useful information from vast quantities of biological data. The method includes pre-processing of training data and test data to add dimensionality or to identify missing or erroneous data points. The training data is used to train the learning machine after which the success of the training is tested using the test data. The test output is pre-processed to determine whether the knowledge discovered from the pre-processed test data set is desirable. After the training has been confirmed, live biological data can be pre-processed then input into the trained learning machine for extraction of useful information. In the preferred embodiment, the learning machine is one or more support vector machines.

Method for enhancing knowledge discovered from biological data using a learning machine

Multiple support vector machines are used to extract useful information from vast quantities of biological data. The method includes pre-processing of training data and test data to add dimensionality or to identify missing or erroneous data points. The training data is used to train the learning machine after which the success of the training is tested using the test data. The test output is pre-processed to determine whether the knowledge discovered from the pre-processed test data set is desirable and to identify which of the multiple support vector machines provides the optimal solution. After the training has been confirmed, live biological data can be pre-processed then input into the identified support vector machine that provides the optimal solution for extraction of useful information.

Enhancing biological knowledge discovery using multiples support vector machines

System for enhancing knowledge discovery from data using a learning machine in general and a support vector machine in particular in a distributed network environment. A customer transmits training data, test data and live data to a vendor's server from a remote source, via a distributed network. The training biological data, test biological data and live biological data is stored in a storage device. Training biological data is then pre-processed in order to add meaning thereto. Pre-processing data involves transforming the biological data points and/or expanding the biological data points. Live biological data is pre-processed and input into the trained and tested learning machine. The live output from the learning machine is then post-processed into a computationally derived alphanumerical classifier for interpretation by a human or computer automated process.

System for identifying patterns in biological data using a distributed network

A system and method for enhancing knowledge discovery from data using multiple learning machines in general and multiple support vector machines in particular. Training data for a learning machine is pre-processed in order to add meaning thereto. Pre-processing data may involve transforming the data points and/or expanding the data points. By adding meaning to the data, the learning machine is provided with a greater amount of information for processing. With regard to support vector machines in particular, the greater the amount of information that is processed, the better generalizations about the data that may be derived. Multiple support vector machines, each comprising distinct kernels, are trained with the pre-processed training data and are tested with test data that is pre-processed in the same manner. The test outputs from multiple support vector machines are compared in order to determine which of the test outputs if any represents a optimal solution. Selection of one or more kernels may be adjusted and one or more support vector machines may be retrained and retested. Optimal solutions based on distinct input data sets may be combined to form a new input data set to be input into one or more additional support vector machine.

Enhancing knowledge discovery from multiple data sets using multiple support vector machines

A system and method for enhancing knowledge discovery from data using multiple learning machines in general and multiple support vector machines in particular. Training data for a learning machine is pre-processed in order to add meaning thereto. Pre-processing data involves transforming the data points and/or expanding the data points. By adding meaning to the data, the learning machine is provided with a greater amount of information for processing. With regard to support vector machines in particular, the greater the amount of information that is processed, the better generalizations about the derived data. Multiple support vector machines, each comprising distinct kernels, are trained with the pre-processed training data and are tested with test data that is pre-processed in the same manner. The test outputs from multiple support vector machines are compared in order to determine which of the test outputs if any represents a optimal solution. Selection of one or more kernels is to be adjusted and one or more support vector machines is to be retrained and retested. When it is determined that an optimal solution has been achieved, live data is pre-processed and input into the support vector machine comprising the kernel that produced the optimal solution. The live output from the learning machine is post-processed into a computationally derived alphanumerical classifier for interpretation by a human or computer automated process.

Enhancing knowledge discovery using multiple support vector machines

The diagnostic method of the present invention provides a method of diagnosing prostate cancer by measuring the concentration of prostate specific antigen and creatine kinase enzyme activity. A mathematical relationship between the two concentrations is then determined. If the prostate specific antigen concentration in the blood is normal or near normal and the creatine kinase enzyme value is lower than normal, than there is a high likelihood that the patient has prostate cancer. The present invention also includes the measurement of creatine kinase enzyme inhibitor in the serum of a patient to determine if the patient has a high likelihood of cancer.

Methods for diagnosing cancer by measuring creatine kinase

The simultaneous multi access reasoning technology system of the present invention utilizes both existing knowledge and implicit information that can be numerically extracted from training data to provide a method and apparatus for diagnosing disease and treating a patient. This technology further comprises a system for receiving patient data from another location, analyzing the data in a trained neural network, producing a diagnostic value, and optionally transmitting the diagnostic value to another location.

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Savannah, GA, United States of America

Stephen D Barnhill