Albion International, Inc.

Albion Laboratories, Inc.

Stephen D Ashmead

Clayton Ericson

David C Wheelwright

Mark Pedersen

Earl C Christiansen

Jennifer W Hartle

H Dewayne Ashmead

Jonathan David Bortz

R Charles Thompson

Robert William Kreitlow

Harvey H Ashmead

Max R Motyka

Rick Harnish

DeWayne Ashmead

Amanda Rees

Robert Kreitlow

Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.

Mixed amino acid/mineral compounds having improved solubility

Hypoallergenic metal amino acid chelate compositions, hypoallergenic formulations containing hypoallergenic metal amino acid chelates, methods of preparing hypoallergenic metal amino acid chelate, and methods of administering hypoallergenic metal amino acid chelates are provided. Specifically, the present invention provides metal amino acid chelates that are substantially free of allergens such that administration of the metal amino acid chelates to a subject in an effective amount to cause a medicinal or nutritional result does not produce a discernable adverse allergic reaction. The metal amino acid chelates can include chelates having a naturally occurring amino acid to metal molar ratio of from about 1:1 to 4:1.

Hypoallergenic metal amino acid chelates and metal amino acid chelate-containing compositions

The present invention includes amino sugar chelates and methods for preparing amino sugar chelates of the formula given below, where M is a metal; Rand Rare independently selected from H, OH and hydroxyl substituted C-Calkyl; Ris selected from H, COH, OH, and hydroxyl substituted C-Calkyl; each Ris independently selected from H, OH, and hydroxyl substituted C-Calkyl; A is selected from CH and O; a is from 0-6; b is from 0-6; n is from 1 to 8. The amino sugar chelates may include matrix stabilizing salts. The compounds and compositions disclosed can be used as nutritional supplements to impart health benefits. 

Amino sugar chelates

A method for determining the amount of metal amino acid chelate present in various chelate compositions. FT-IR is used to determine the amount of free amino acid present. The bound amino acids may be in the form of an amino acid complex or an amino acid chelate. A total metal analysis and measurement of ligand quantity is then performed, from which the percent of metal amino acid chelate in the sample is calculated.

Process for determining the percent of chelation in a dry mixture

A mineral fortified food matrix can comprise a dimetalhydroxy malate composition and a food matrix fortified with the dimetalhydroxy malate composition. Additionally, a method of administering a mineral in a bioavailable form to a warm-blooded animal can comprise steps of fortifying a food matrix with a dimetalhydroxy malate composition and orally administering the food matrix to a warm-blooded animal. In one embodiment, the mineral can be calcium and the method of administering calcium in a bioavailable form can comprise fortifying a food matrix with a dicalciumhydroxy malate composition.

Dimetalhydroxy malate fortified food matrices

A composition and method of preparing amino acid chelates and complexes free of interfering ions by blending an amino acid ligand, a calcium oxide and/or hydroxide, and a hydrated metal sulfate salt, placing the blend in a closed environment, heating the blend, and allowing the blend to react is disclosed and described. By heating at low to moderate temperatures in an enclosed environment, the waters of hydration of the metal salt are retained in the enclosed environment and serve to provide the moisture necessary to enable a bonding reaction to take place between the electron rich functional groups of the ligand and the metal ion of the hydrated metal sulfate salt. Additionally, calcium sulfate is formed which can be maintained in the final product.

Composition and method for preparing amino acid chelates and complexes free of interfering complex ions

Dimetalhydroxy malate compositions as well as methods of administering and making such bioavailable compositions are provided. The metal used can be any nutritionally relevant divalent metal such as calcium, magnesium, zinc, copper, manganese, and iron. The composition can be prepared by reacting malic acid with a divalent metal oxide or hydroxide at a 1:2 molar ratio. The composition can be administered to a warm-blooded animal by any of a number of known delivery routes, including oral delivery.

Dimetalhydroxy malates

The present invention relates to compositions and methods of preparing amino acid chelates that are essentially free of interfering ions. The composition is prepared by reacting in an aqueous solution, a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially all of the ions present in solution to react forming a positively charged metal amino acid chelate having a hydroxide counter-ion, and calcium sulfate, and wherein the metal amino acid chelate has a ligand to metal molar ratio from 1:1 to 2:1.

Composition and method for preparing amino acid chelate hydroxides free of interfering ions

Compositions and methods of preparing amino acid chelates and complexes are disclosed and described. Specifically, by (a) blending hydrated metal sulfate salts, amino acid ligands, and reaction modifiers; (b) confining the particulate blend in an enclosed environment; and (c) applying heat to the particulate blend in the enclosed environment causing the waters of hydration of the metal sulfate salt to be released into the enclosed environment causing a reaction resulting in the formation of a granular amino acid chelate or complex by effecting the reaction between functional electron rich groups of the amino acid ligand and a metal ion of the metal sulfate salt. The waters of hydration serve to provide the water necessary to enable a bonding reaction to take place between the electron rich functional groups of the amino acid ligand and the metal ion of the hydrated metal sulfate salt.

Composition and method for preparing granular amino acid chelates and complexes

The present invention relates to compositions and methods of preparing amino acid chelates that are electrically neutral and free of interfering ions. The composition is prepared by reacting in an aqueous solution a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially all of the ions present in solution to react forming a metal amino acid chelate and an essentially inert calcium sulfate, and wherein the metal amino acid chelate has a ligand to metal molar ratio from 2:1 to 3:1.

Composition and method for preparing electrically neutral amino acid chelates free of interfering ions

Calcium amino acid chelate complexes for fortification of dairy products and oleaginous foods, dairy products and oleaginous foods fortified with calcium amino acid chelate complexes, and methods of preparing calcium amino acid chelate complexes are disclosed and described. The calcium amino acid chelate complexes of the present invention are stable, palatable, and bioavailable. Preparation steps include reacting a calcium compound, an amino acid ligand, a pH adjuster, and, optionally, a stabilizing/suspending agent in an aqueous environment.

Compositions and methods for calcium fortification of dairy products and oleaginous foods

A calcium amino acid malic acid chelate complex for fortification of oleagnious foods which is stable, bioavailable, and palatable is disclosed. Further, oleaginous foods fortified with the calcium amino acid malic acid chelate complexes of the present invention are also disclosed. The calcium amino acid malic acid chelate complex is prepared by reacting a calcium source, an amino acid ligand, and malic acid in an aqueous environment.

Calcium fortification of oleaginous foods

A cereal grain kernel coated with a metal amino acid chelate, a method for mineral or metal fortification of cereal grain kernels and a coating composition is disclosed. Unlike other metal or mineral fortificants, cereal grain kernels may be coated with iron, calcium, zinc and/or other metals in the form of an amino acid chelate without pulverizing individual kernels. Further, the coated kernels are stable, palatable and contain highly bioavailable metals.

Cereal grain kernels fortified with amino acid chelates and method of making

A zinc amino acid chelate formulation is disclosed comprising zinc ions being chelated by an amino acid ligand mixture comprising glycine and a sulfur-containing amino acid wherein the ligand to zinc molar ratio is from about 1:1 to 2:1 and wherein the glycine to sulfur-containing amino acid molar ratio is between about 1:6 to 6:1.

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Clinton, UT, United States of America

Stephen D Ashmead