Dow Agrosciences LLC

Basf Se Corporation

Lexington Pharmaceuticals Laboratories, LLC

Corteva Agriscience LLC

Stephen Craig Fields

Christian Thomas Lowe

Paul R Schmitzer

Patricia Andres

Jeffrey Brian Epp

Terry William Balko

Jennifer Leigh Nelson

Brian Michael Green

Matthew Richard Oberholzer

Samir Kulkarni

Thomas L Siddall

Ann Marie Buysse

Joseph D Eckelbarger

Natalie Christine Giampietro

Lindsey Gayle Fischer

Katherine Anne Guenthenspberger

William Chi-Leung Lo

Norbert M Satchivi

William C Lo

Jeff Petkus

Joshua Roth

Nicholas Martin Irvine

Nick X Wang

William Randal Erickson

James M Ruiz

William Kirkland Brewster

Renee Joan Keese

John Sanders Richburg, Iii

Paul Richard Schmitzer

Jeffery Dale Webster

Kristy Bryan

Monte Ray Weimer

Paul Richard Graupner

Karl L Krumel

Anita L Alexander

Lindsey G Horty

Roger Eugene Gast

John Sanders Richburg

Ben Clifford Gerwick, Iii

Norbet M Satchivi

Renard Antonio Green

Leslie Anne Bjelk

Katherine A Guenthenspberger

William Chi-Leug Lo

John Sanders Iii Richburg

Renee Keese

Karl Krumel

John Richburg

James Melvin Ruiz

Leslie A Bjekl

Lindsey G Fischer

Natalie C Giampietro

William Randall Erickson

Thomas L Siddal

Christian T Lowe

Jeffrey B Epp

Ben Clifford Gerwick

Jeffrey Dale Webster

Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are described.

Methods for the purification of L-glufosinate

Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.

4-Amino-6-(heterocyclic)picolinic acids and their derivatives; 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.

4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides

Disclosed is a method of chlorinating a carbohydrate or derivative thereof, for example, a sucrose-6-ester at the 4,1', and 6&#x2032; positions, with irreversible removal of HCl formed during the reaction to form the chlorinated carbohydrate or derivative thereof, for example, a 4,1&#x2032;,6&#x2032;-trichloro-4,1&#x2032;,6&#x2032;-trideoxy-6-O-ester of galactosucrose (TGS-6E). The irreversible removal of HCl can be carried out by an irreversible physical process and/or an irreversible chemical process. Sucralose, an artificial sweetener, can be prepared by deesterification of the TGS-6E. The chlorination reaction takes place at low temperatures and the desired chlorinated product is obtained in high yields and in high purities.

Low temperature, vacuum assisted chlorination of sucrose-6-esters free of overchlorinated by-products as intermediates for the production of the artificial sweetener, sucralose

Disclosed is a method for chlorinating a carbohydrate or a derivative thereof to produce a polychlorinated carbohydrate or a derivative thereof, such as sucralose, the method involves (i) reacting the carbohydrate or derivative thereof with a chlorinating agent to obtain a reaction mixture comprising said polychlorinated carbohydrate or derivative thereof and at least one under-chlorinated carbohydrate or derivative thereof, (ii) returning the at least one under-chlorinated carbohydrate or derivative thereof to a chlorinating step and further chlorinating the at least one under-chlorinated carbohydrate or derivative thereof to obtain the desired polychlorinated carbohydrate or derivative thereof; and (iii) optionally repeating steps (i) and (ii) 'n' times where n&#x2267;1. The polychlorinated carbohydrate or a derivative thereof is obtained in high yields.

Chlorination of carbohydrates and carbohydrate derivatives

4-Aminopicolinic acids having alkyl or alkenyl substituents in the 6-position and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control.

6-alkyl or alkenyl-4-aminopicolinates and their use as herbicides

Methylidene mevalonic acid, a material isolated from a fungal extract, and its primary alcohol and carboxylic acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control. These materials are useful for weed control and for the cultivation of organically grown crops.

Methylidene mevalonates and their use as herbicides

4-Aminopicolinic acids having (1,1-difluoroalkyl) substituents in the 6-position and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control.

6-(1,1-difluoroalkyl)-4-aminopicolinates and their use as herbicides

4-Aminopicolinic acids having aryl or heteroaryl substituents in the 6-position and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control.

6-aryl-4-aminopicolinates and their use as herbicides

4-Aminopicolinic acids, having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents in the 3-, 5- and 6-positions, and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control.

4-aminopicolinates and their use as herbicides

Growing community of inventors

Indianapolis, IN, United States of America

Stephen Craig Fields